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Fluorescent phosphorus dendrimer as a spectral nanosensor for macrophage polarization and fate tracking in spinal cord injury

2015Journal article Open access
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dc.contributor.authorShakhbazau, Antos
dc.contributor.authorMishra, Manoj
dc.contributor.authorChu, Tak‐Ho
dc.contributor.authorBrideau, Craig
dc.contributor.authorCummins, Karen
dc.contributor.authorTsutsui, Shigeki
dc.contributor.authorShcharbin, Dzmitry
dc.contributor.authorMajoral, Jean‐Pierre
dc.contributor.authorMignani, Serge
dc.contributor.authorBlanchard‐Desce, Mireille
dc.contributor.authorBryszewska, Maria
dc.contributor.authorYong, V. Wee
dc.contributor.authorStys, Peter K.
dc.contributor.authorvan Minnen, Jan
dc.date.accessioned2024-02-28T14:32:10Z
dc.date.available2024-02-28T14:32:10Z
dc.date.issued2015
dc.description.abstractDendrimers and dendriplexes, highly branched synthetic macromolecules, have gained popularity as new tools for a variety of nanomedicine strategies due to their unique structure and properties. We show that fluorescent phosphorus dendrimers are well retained by bone marrow-derived macrophages and exhibit robust spectral shift in its emission in response to polar ization conditions. Fluorescence properties of this marker can also assist in identifying macrophage presence and phenotype status at different time points after spinal cord injury. Potential use of a single dendrimer compound as a drug/siRNA carrier and phenotype-specific cell tracer offers new avenues for enhanced cell therapies combined with monitor ing of cell fate and function in spinal cord injury.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationShakhbazau, A., Mishra, M., Chu, T. H., Brideau, C., Cummins, K., Tsutsui, S., ... & Van Minnen, J. (2015). Fluorescent phosphorus dendrimer as a spectral nanosensor for macrophage polarization and fate tracking in spinal cord injury. Macromolecular bioscience, 15(11), 1523-1534.pt_PT
dc.identifier.doi10.1002/mabi.201500150pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/5588
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectMacrophage polarizationpt_PT
dc.subjectSpinal cord injurypt_PT
dc.subjectFluorescent phosphorus dendrimerpt_PT
dc.subjectCell trackerpt_PT
dc.subjectSpectralpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.titleFluorescent phosphorus dendrimer as a spectral nanosensor for macrophage polarization and fate tracking in spinal cord injurypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1534pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage1523pt_PT
oaire.citation.titleMacromolecular Biosciencept_PT
oaire.citation.volume15pt_PT
person.familyNameMignani
person.givenNameSerge
person.identifier.ciencia-id8018-B5D2-6983
person.identifier.orcid0000-0002-1383-5256
person.identifier.scopus-author-id7003374430
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcabd0aa0-5827-4e97-889b-922136d2dd4b
relation.isAuthorOfPublication.latestForDiscoverycabd0aa0-5827-4e97-889b-922136d2dd4b

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