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Publicação
Fluorescent phosphorus dendrimer as a spectral nanosensor for macrophage polarization and fate tracking in spinal cord injury
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Orientador(es)
Resumo(s)
Dendrimers and dendriplexes, highly branched synthetic macromolecules, have gained
popularity as new tools for a variety of nanomedicine strategies due to their unique structure
and properties. We show that fluorescent phosphorus dendrimers are well retained by bone
marrow-derived macrophages and exhibit robust
spectral shift in its emission in response to polar ization conditions. Fluorescence properties of this
marker can also assist in identifying macrophage
presence and phenotype status at different time
points after spinal cord injury. Potential use of a
single dendrimer compound as a drug/siRNA carrier
and phenotype-specific cell tracer offers new avenues
for enhanced cell therapies combined with monitor ing of cell fate and function in spinal cord injury.
Descrição
Palavras-chave
Macrophage polarization Spinal cord injury Fluorescent phosphorus dendrimer Cell tracker Spectral . Faculdade de Ciências Exatas e da Engenharia
Contexto Educativo
Citação
Shakhbazau, A., Mishra, M., Chu, T. H., Brideau, C., Cummins, K., Tsutsui, S., ... & Van Minnen, J. (2015). Fluorescent phosphorus dendrimer as a spectral nanosensor for macrophage polarization and fate tracking in spinal cord injury. Macromolecular bioscience, 15(11), 1523-1534.
Editora
Wiley