Fluorescent phosphorus dendrimer as a spectral nanosensor for macrophage polarization and fate tracking in spinal cord injury

Shakhbazau, Antos; Mishra, Manoj; Chu, Tak‐Ho; Brideau, Craig; Cummins, Karen; Tsutsui, Shigeki; Shcharbin, Dzmitry; Majoral, Jean‐Pierre; Mignani, Serge; Blanchard‐Desce, Mireille; Bryszewska, Maria; Yong, V. Wee; Stys, Peter K.; van Minnen, Jan

http://hdl.handle.net/10400.13/5588

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Authors

Blanchard‐Desce, Mireille

Abstract(s)

Dendrimers and dendriplexes, highly branched synthetic macromolecules, have gained popularity as new tools for a variety of nanomedicine strategies due to their unique structure and properties. We show that fluorescent phosphorus dendrimers are well retained by bone marrow-derived macrophages and exhibit robust spectral shift in its emission in response to polar ization conditions. Fluorescence properties of this marker can also assist in identifying macrophage presence and phenotype status at different time points after spinal cord injury. Potential use of a single dendrimer compound as a drug/siRNA carrier and phenotype-specific cell tracer offers new avenues for enhanced cell therapies combined with monitor ing of cell fate and function in spinal cord injury.

Keywords

Macrophage polarization Spinal cord injury Fluorescent phosphorus dendrimer Cell tracker Spectral . Faculdade de Ciências Exatas e da Engenharia

URI

http://hdl.handle.net/10400.13/5588

Citation

Shakhbazau, A., Mishra, M., Chu, T. H., Brideau, C., Cummins, K., Tsutsui, S., ... & Van Minnen, J. (2015). Fluorescent phosphorus dendrimer as a spectral nanosensor for macrophage polarization and fate tracking in spinal cord injury. Macromolecular bioscience, 15(11), 1523-1534.