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Madeira moneywort (Sibthorpia peregrina L.) as a new source of verbascoside and its derivatives with potential phyto-pharmaceutical applications

2018Journal article Open access
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dc.contributor.authorSpínola, Vítor
dc.contributor.authorCastilho, Paula C.
dc.date.accessioned2021-03-25T15:57:37Z
dc.date.available2021-03-25T15:57:37Z
dc.date.issued2018
dc.description.abstractThe qualitative and quantitative characterization of Madeira moneywort (Sibthorpia peregrina L.) compounds was investigated for the first time. The antioxidant activity and the effect of the methanolic extract on digestive enzymes activity linked to type-2 diabetes and obesity were also determined by in vitro assays. A total of 56 components were characterized in S. peregrina. Phenylethanoids glycosides (PhEGs) represented the main classes of compounds (95.23 mg g-1 of dry extract), almost all verbascoside and its derivatives (up to 98.85% of the total individual phenolic content). The analysed sample was active against ABTS, DPPH, nitric oxide and superoxide radicals, suggesting a potential beneficial effect against oxidative stress. In addition, the methanolic extract was able to inhibit the catalytic activity of α-, β-glucosidases, α-amylase and pancreatic lipase. Overall, S. peregrina showed good perspectives to be explored as a rich source of verbascoside and its derivatives for nutraceutical/pharmaceutical products.pt_PT
dc.description.sponsorshipThis work was supported by Fundação para a Ciência e a Tecnologia (FCT, Portugal) [grant number SFRH/ BD/84672/2012] with funds from the Portuguese Government (Project PEst-OE/QUI/UI0674/2013) and the Portuguese National Mass Spectrometry Network (Contract RNEMREDE/1508/REM/2005). Funding through the project M1420-01-0145-FEDER-000005 – Centro de Química da Madeira – CQM+(Madeira 14-20).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSpínola, V., & Castilho, P. C. (2019). Madeira moneywort (Sibthorpia peregrina L.) as a new source of verbascoside and its derivatives with potential phyto-pharmaceutical applications. Natural product research, 33(22), 3321-3325. 10.1080/14786419.2018.1474354pt_PT
dc.identifier.doi10.1080/14786419.2018.1474354pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/3205
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor and Francispt_PT
dc.relationNUTRACEUTICALS AND FUNCTIONAL FOODS FOR DIABETES AND OBESITY CONTROL
dc.relationStrategic Project - UI 674 - 2014
dc.subjectSibthorbia peregrina L.pt_PT
dc.subjectMadeira moneyworpt_PT
dc.subjectPhenolic compositionpt_PT
dc.subjectVerbascosidept_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectDigestive enzymes inhibitionpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleMadeira moneywort (Sibthorpia peregrina L.) as a new source of verbascoside and its derivatives with potential phyto-pharmaceutical applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNUTRACEUTICALS AND FUNCTIONAL FOODS FOR DIABETES AND OBESITY CONTROL
oaire.awardTitleStrategic Project - UI 674 - 2014
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F84672%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0674%2F2014/PT
oaire.citation.endPage3325pt_PT
oaire.citation.issue22pt_PT
oaire.citation.startPage3321pt_PT
oaire.citation.titleNatural Product Researchpt_PT
oaire.citation.volume33pt_PT
oaire.fundingStreamOE
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSpínola
person.familyNameCastilho
person.givenNameVítor
person.givenNamePaula C
person.identifierA-4412-2013
person.identifier.ciencia-id6D15-8C69-A2E0
person.identifier.orcid0000-0003-2456-8613
person.identifier.orcid0000-0002-8303-4286
person.identifier.scopus-author-id54881258000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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