Repository logo
 
Publication

Evaluation of Asteraceae herbal extracts in the management of diabetes and obesity. Contribution of caffeoylquinic acids on the inhibition of digestive enzymes activity and formation of advanced glycation end-products (in vitro)

dc.contributor.authorSpínola, Vítor
dc.contributor.authorCastilho, Paula C.
dc.date.accessioned2021-03-26T11:41:07Z
dc.date.available2021-03-26T11:41:07Z
dc.date.issued2017
dc.description.abstractThe study was performed to assess, for the first time, the in vitro anti-diabetic potential of ten Asteraceae plant extracts to inhibit the activity of digestive enzymes (α-amylase, α-, β-glucosidases and lipase) responsible for hydrolysis/digestion of sugar and lipids. Prevention of advanced glycation end-products (AGEs) formation was evaluated in bovine serum albumin/ribose glycation reaction model. The phytochemical profiles and caffeoylquinic acids (CQAs) contents were determined for the methanolic extract of each plant. Analyzed plant extracts exhibited significant inhibitory activity against key digestive enzymes linked to type II diabetes and obesity. A strong inhibition was observed for glucosidases and mild activity towards amylase and lipase (compared to reference compounds). Moreover, some extracts exhibited potent ability to prevent formation of AGEs, implicated in some diabetic complications. Caffeoylquinic acids were dominant in all plant extracts and findings demonstrate that these compounds are the most relevant hypoglycemic and anti-glycation agents. From the obtained results, Argyranthemum pinnatifidum, Helichrysum melaleucum, and Phagnalon lowei are good candidates for further development of phyto-pharmaceutical preparations as complementary therapy for diabetes and obesity control.pt_PT
dc.description.sponsorshipThe authors are grateful to Francisco Fernandes and Jose Carvalho from Madeira Botanical Garden and to Funchal Ecological Park for the supply and identification of plant material.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSpínola, V., & Castilho, P. C. (2017). Evaluation of Asteraceae herbal extracts in the management of diabetes and obesity. Contribution of caffeoylquinic acids on the inhibition of digestive enzymes activity and formation of advanced glycation end-products (in vitro). Phytochemistry, 143, 29-35. 10.1016/j.phytochem.2017.07.006pt_PT
dc.identifier.doi10.1016/j.phytochem.2017.07.006pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/3208
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPhytochemical Society of Europept_PT
dc.relationStrategic Project - UI 674 - 2014
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAsteraceae plantspt_PT
dc.subjectCaffeoylquinic acidspt_PT
dc.subjectHyperglycaemiapt_PT
dc.subjectDigestive enzymes inhibitionpt_PT
dc.subjectAdvanced glycation end-productspt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleEvaluation of Asteraceae herbal extracts in the management of diabetes and obesity. Contribution of caffeoylquinic acids on the inhibition of digestive enzymes activity and formation of advanced glycation end-products (in vitro)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 674 - 2014
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F84672%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0674%2F2014/PT
oaire.citation.endPage35pt_PT
oaire.citation.startPage29pt_PT
oaire.citation.titlePhytochemistrypt_PT
oaire.citation.volume143pt_PT
oaire.fundingStreamSFRH
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSpínola
person.familyNameCastilho
person.givenNameVítor
person.givenNamePaula C
person.identifierA-4412-2013
person.identifier.ciencia-id6D15-8C69-A2E0
person.identifier.orcid0000-0003-2456-8613
person.identifier.orcid0000-0002-8303-4286
person.identifier.scopus-author-id54881258000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication6bf71312-4006-4df6-9fbe-d9ed8ce12b06
relation.isAuthorOfPublicationd84fd917-438e-43bf-ac6f-256562481c05
relation.isAuthorOfPublication.latestForDiscovery6bf71312-4006-4df6-9fbe-d9ed8ce12b06
relation.isProjectOfPublication34751b34-607a-473a-bc2e-ffc6b725cf18
relation.isProjectOfPublication75aaadc4-cd17-4fec-ba9d-1d0e564b3731
relation.isProjectOfPublication.latestForDiscovery34751b34-607a-473a-bc2e-ffc6b725cf18

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Evaluation of Asteraceae herbal extracts in the management of diabetes and obesity. Contribution of caffeoylquinic acids on the inhibition of digestive enzymes activity and formation of advanced glycation.pdf
Size:
423.14 KB
Format:
Adobe Portable Document Format