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Carbosilane glycodendrimers for anticancer drug delivery: synthetic route, characterization, and biological effect of Glycodendrimer–Doxorubicin complexes

2021Journal article Open access
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dc.contributor.authorMüllerová, Monika
dc.contributor.authorMaciel, Dina
dc.contributor.authorNunes, Nádia
dc.contributor.authorWrobel, Dominika
dc.contributor.authorStofik, Marcel
dc.contributor.authorČervenková Št́astná, Lucie
dc.contributor.authorKrupková, Alena
dc.contributor.authorCuřínová, Petra
dc.contributor.authorNováková, Kateřina
dc.contributor.authorBožík, Matěj
dc.contributor.authorMalý, Marek
dc.contributor.authorMalý, Jan
dc.contributor.authorRodrigues, João
dc.contributor.authorStrašák, Tomáš
dc.date.accessioned2022-03-08T15:25:01Z
dc.date.available2022-12-31T01:30:14Z
dc.date.issued2021
dc.description.abstractThe complexity of drug delivery mechanisms calls for the development of new transport system designs. Here, we report a robust synthetic procedure toward stable glycodendrimer (glyco-DDM) series bearing glucose, galactose, and oligo(ethylene glycol)-modified galactose peripheral units. In vitro cytotoxicity assays showed exceptional biocompatibility of the glyco-DDMs. To demonstrate applicability in drug delivery, the anticancer agent doxorubicin (DOX) was encapsulated in the glyco-DDM structure. The anticancer activity of the resulting glyco-DDM/DOX complexes was evaluated on the noncancerous (BJ) and cancerous (MCF-7 and A2780) cell lines, revealing their promising generation- and concentration-dependent effect. The glyco DDM/DOX complexes show gradual and pH-dependent DOX release profiles. Fluorescence spectra elucidated the encapsulation process. Confocal fluorescence microscopy demonstrated preferential cancer cell internalization of the glyco-DDM/DOX complexes. The conclusions were supported by computer modeling. Overall, our results are consistent with the assumption that novel glyco DDMs and their drug complexes are very promising in drug delivery and related applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMullerova, M., Maciel, D., Nunes, N., Wrobel, D., Stofik, M., Červenková Št́astná, L., ... & Strašák, T. (2021). Carbosilane Glycodendrimers for Anticancer Drug Delivery: Synthetic Route, Characterization, and Biological Effect of Glycodendrimer–Doxorubicin Complexes. Biomacromolecules.pt_PT
dc.identifier.doi10.1021/acs.biomac.1c01264pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/4126
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Chemical Societypt_PT
dc.relationMadeira Chemistry Research Centre
dc.relationMadeira Chemistry Research Centre
dc.relationDendrimers and Dendrons Ruthenium-based Nanosystems to tackle Challenging Cancers
dc.subjectCarbosilane glycodendrimerspt_PT
dc.subjectAnticancer drug deliverypt_PT
dc.subjectGlycodendrimerpt_PT
dc.subjectDoxorubicin complexespt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleCarbosilane glycodendrimers for anticancer drug delivery: synthetic route, characterization, and biological effect of Glycodendrimer–Doxorubicin complexespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardTitleDendrimers and Dendrons Ruthenium-based Nanosystems to tackle Challenging Cancers
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00674%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00674%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//2020.04679.BD/PT
oaire.citation.endPage290pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage276pt_PT
oaire.citation.titleBiomacromoleculespt_PT
oaire.citation.volume23pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMaciel
person.familyNameRodrigues
person.givenNameDina
person.givenNameJoão
person.identifier.ciencia-id211C-6048-FB1A
person.identifier.ciencia-idA81C-620E-DD6A
person.identifier.orcid0000-0001-8684-6100
person.identifier.orcid0000-0003-4552-1953
person.identifier.ridB-6816-2008
person.identifier.scopus-author-id54781586200
person.identifier.scopus-author-id9233278800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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