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pH sensitive mesoporous nanohybrids with charge-reversal properties for anticancer drug delivery

2017Journal article Open access
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dc.contributor.authorWu, Bozhen
dc.contributor.authorDeng, Shunshu
dc.contributor.authorZhang, Shihao
dc.contributor.authorJiang, Jia
dc.contributor.authorHan, Baosan
dc.contributor.authorLi, Yulin
dc.date.accessioned2023-11-03T11:59:11Z
dc.date.available2023-11-03T11:59:11Z
dc.date.issued2017
dc.description.abstractThe surface/interface state of nanomaterials plays a key role on their biomedical applications. Nanotechnology offers a versatile means to develop nanoparticles with well-defined architecture. In this study, mesoporous silica nanoparticles were firstly loaded with an anticancer drug (doxorubicin, DOX), which were then decorated with a cationic oligomer (low molecular weight polyethyleneimine, LPEI) to acquire an increased surface charge. The resulting particles were further self-assembled with negative-charged bovine serum albumin (BSA) as natural protein nanoblocks to offer surface charge tunability. The resulting mesoporous nanohybrids (MDPB) acquired charge-reversal ability, which presented negative charge under biological conditions (beneficial to biocompatibility), while displaying a positive-charged state under acidic conditions mimicking the tumor extracellular microenvironment (favoring cell uptake or tumor penetration). Furthermore, the nanohybrids not only allowed for an effective loading of DOX drug, but also accelerated its release under acidic tumor microenvironments in a sustainable way. In vitro biological study indicated that the DOX-free nanoparticles were biocompatible, while MDPB exerted good cytotoxicity against cancer cells, suggesting their promise for therapeutic delivery application.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationWu, B., Deng, S., Zhang, S., Jiang, J., Han, B., & Li, Y. (2017). pH sensitive mesoporous nanohybrids with charge-reversal properties for anticancer drug delivery. RSC advances, 7(73), 46045-46050.pt_PT
dc.identifier.doi10.1039/C7RA05912Dpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/5344
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherRoyal Society of Chemistrypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectAnticancer drug deliverypt_PT
dc.subjectpH sensitive mesoporous nanohybridspt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.titlepH sensitive mesoporous nanohybrids with charge-reversal properties for anticancer drug deliverypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage46050pt_PT
oaire.citation.issue73pt_PT
oaire.citation.startPage46045pt_PT
oaire.citation.titleRSC Advancespt_PT
oaire.citation.volume7pt_PT
person.familyNameLi
person.givenNameYulin
person.identifier.orcid0000-0001-5569-1038
person.identifier.ridA-4082-2013
person.identifier.scopus-author-id55718977200
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationde21a0a9-a5a2-4521-b0e4-5902704f9bb0
relation.isAuthorOfPublication.latestForDiscoveryde21a0a9-a5a2-4521-b0e4-5902704f9bb0

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