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Recent therapeutic applications of the theranostic principle with dendrimers in oncology

2018Journal article Restricted access
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dc.contributor.authorMignani, Serge
dc.contributor.authorRodrigues, João
dc.contributor.authorTomás, Helena
dc.contributor.authorCaminade, Anne-marie
dc.contributor.authorLaurent, Régis
dc.contributor.authorShi, Xiangyang
dc.contributor.authorMajoral, Jean-Pierre
dc.date.accessioned2019-06-28T08:39:10Z
dc.date.available2019-06-28T08:39:10Z
dc.date.issued2018
dc.description.abstractAt the intersection between treatment and diagnosis,nanoparticlestechnologiesarestronglyimpactingthe development of both therapeutic and diagnostic agents. Consequently, the development of novel modalities for concomitant noninvasive therapy and diagnostics known as theranostics as a single platform has gained significant interests. These multifunctional theranostic platforms include carbon-based nanomaterials (e.g., carbon nanotubes), drug conjugates, aliphatic polymers, micelles, vesicles, core-shell nanoparticles,microbubblesanddendrimersbearingdifferent contrastagentsanddrugs,suchascytotoxiccompoundsinthe oncology domain. Dendrimers emerged as a new class of highly tunable hyperbranched polymers, and have been developed as useful theranostic platforms. Magnetic resonance imaging, gamma scintigraphy, computed tomography and optical imaging are the main techniques developed with dendrimers in the theranostic domain in oncology. Different imaging agents have been used such as Gd(III), 19F, Fe2O3 (MRI), 76Br (PET), 111In, 88Y, 153Gd, 188Re, 131I (SPECT), 177Lu, gold (CT) and boronated groups, siliconnaphthalocyanines, dialkylcarbocyanines and QDs (optical imaging dyes).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMignani, S., Rodrigues, J., Tomas, H., Caminade, A. M., Laurent, R., Shi, X., & Majoral, J. P. (2018). Recent therapeutic applications of the theranostic principle with dendrimers in oncology. Science China Materials, 61(11), 1367-1386.pt_PT
dc.identifier.doi10.1007/s40843-018-9244-5pt_PT
dc.identifier.issn2095-8226
dc.identifier.urihttp://hdl.handle.net/10400.13/2440
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Verlagpt_PT
dc.relationStrategic Project - UI 674 - 2014
dc.subjectTheranostic platformspt_PT
dc.subjectDendrimerspt_PT
dc.subjectMagnetic resonance imagingpt_PT
dc.subjectGamma scintigraphy imagingpt_PT
dc.subjectComputed tomography imagingpt_PT
dc.subjectOptical imagingpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleRecent therapeutic applications of the theranostic principle with dendrimers in oncologypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 674 - 2014
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0674%2F2014/PT
oaire.citation.endPage1386pt_PT
oaire.citation.startPage1367pt_PT
oaire.citation.titleScience China Materialspt_PT
oaire.citation.volume61(11)pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMignani
person.familyNameRodrigues
person.familyNameTomás
person.familyNameCaminade
person.familyNameShi
person.givenNameSerge
person.givenNameJoão
person.givenNameHelena
person.givenNameAnne-marie
person.givenNameXiangyang
person.identifier556975
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person.identifier.orcid0000-0002-1383-5256
person.identifier.orcid0000-0003-4552-1953
person.identifier.orcid0000-0002-7856-2041
person.identifier.orcid0000-0001-8487-3578
person.identifier.orcid0000-0001-6785-6645
person.identifier.ridB-6816-2008
person.identifier.ridE-5991-2010
person.identifier.ridE-2819-2015
person.identifier.ridA-1289-2007
person.identifier.scopus-author-id7003374430
person.identifier.scopus-author-id9233278800
person.identifier.scopus-author-id6508104177
person.identifier.scopus-author-id7402953116
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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