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Advisor(s)
Abstract(s)
The present work aims to prepare copper-doped MgO nanoparticles via a sol-gel approach and study their
antidiabetic alpha-amylase inhibition activity with undoped MgO nanoparticles. The ability of G5 amine terminated polyamidoamine (PAMAM) dendrimer for the controlled release of copper-doped MgO nano particles to exhibit alpha-amylase inhibition activity was also evaluated. The synthesis of MgO nanoparticles via
sol-gel approach and optimization of calcination temperature and time has led to the formation of nanoparticles
with different shapes (spherical, hexagonal, and rod-shaped) and a polydispersity in size ranging from 10 to 100
nm with periclase crystalline phase. The presence of copper ions in the MgO nanoparticles has altered their
crystallite size, eventually modifying their size, morphology, and surface charge. The efficiency of dendrimer to
stabilize spherical copper-doped MgO nanoparticles (ca. 30 %) is higher than in other samples, which was
confirmed by UV–Visible, DLS, FTIR, and TEM analysis. The amylase inhibition assay emphasized that the
dendrimer nanoparticles stabilization has led to the prolonged enzyme inhibition ability of MgO and copper doped MgO nanoparticles for up to 24 h.
Description
Keywords
MgO nanoparticles Dendrimers Dopants Antidiabetic activity Alpha-amylase enzyme Centro de Química da Madeira . Faculdade de Ciências Exatas e da Engenharia
Citation
Publisher
Elsevier BV