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Study on the cyclization of 6-arylethynylpyrimidine-5-carbaldehydes with tert-butylamine: microwave versus thermal preparation of pyrido[4,3-d]pyrimidines
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Orientador(es)
Resumo(s)
Thermal and microwave initiated cyclization of 2,4-disubstituted 6-arylethynylpyrimidine-5-carbalde hydes with tert-butylamine has been studied. A novel high-yielding preparation of 2,4-disubstituted 7-
arylpyrido[4,3-d]pyrimidines has been developed. The intermediate compounds were isolated and
possible mechanism of the reactions is discussed.
Descrição
Palavras-chave
Cyclization Microwave 6-Arylethynylpyrimidine-5-carbaldehydes Pyrido[4,3-d]pyrimidines 1,6-Electrocyclic reaction . Faculdade de Ciências Exatas e da Engenharia
Contexto Educativo
Citação
Cikotiene, I., Kairys, V., Buksnaitiene, R., Morkunas, M., Rudys, S., Brukstus, A., & Fernandes, M. X. (2009). Study on the cyclization of 6-arylethynylpyrimidine-5-carbaldehydes with tert-butylamine: microwave versus thermal preparation of pyrido [4, 3-d] pyrimidines. Tetrahedron, 65(29-30), 5752-5759.
Editora
Elsevier