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Metabolic profiling and antibacterial activity of Eryngium pristis Cham. & Schltdl. - prospecting for its use in the treatment of bacterial infections

2021Journal article Open access
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dc.contributor.authorFernandes, Laura Silva
dc.contributor.authorCosta, Ygor Ferreira Garcia da
dc.contributor.authorBessa, Martha Eunice de
dc.contributor.authorFerreira, Adriana Lucia Pires
dc.contributor.authorCorrêa, José Otávio do Amaral
dc.contributor.authorDel-Vechio Vieira, Glauciemar
dc.contributor.authorSousa, Orlando Vieira de
dc.contributor.authorAraújo, Ana Lúcia Santos de Matos
dc.contributor.authorCastilho, Paula C.
dc.contributor.authorAlves, Maria Silvana
dc.date.accessioned2022-09-30T11:04:03Z
dc.date.available2022-09-30T11:04:03Z
dc.date.issued2021
dc.description.abstractMorbidity and mortality of the infected patients by multidrug-resistant bacteria have increased, emphasizing the urgency of fi ght for the discovery of new innovative antibiotics. In this sense, natural products emerge as valuable sources of bioactive compounds. Among the biodiversity, Eryngium pristis Cham. & Schltdl. (Apiaceae Lindl.) is traditionally used to treat thrush and ulcers of throat and mouth, as diuretic and emmenagogue, but scarcely known as an antimicrobial agent. With this context in mind, the goals of this study were to investigate the metabolic profi le and the antibacterial activity of ethanolic extract (EE-Ep) and hexane (HF-Ep), dichloromethane (DF-Ep), ethyl acetate (EAF-Ep) and butanol (BF-Ep) fractions from E. pristis leaves. Gas Chromatography-Mass Spectrometry (GC-MS) was performed to stablish the metabolic profi le and revealed the presence of 12 and 14 compounds in EAF-Ep and HF-Ep, respectively. β-selinene, spathulenol, globulol, 2-methoxy-4-vinylphenol, α-amyrin, β-amyrin, and lupeol derivative were some of phytochemicals identifi ed. The antibacterial activity was determined by Minimal Inhibitory Concentration (MIC) using the broth micro-dilution against eight ATCC® and fi ve methicillin-resistant Staphylococcus aureus (MRSA) clinical strains. HF-Ep was the most eff ective (MIC ≤ 5,000 μg/μL), being active against the largest part of tested Gram-positive and Gram-negative bacterial strains, including MRSA, with exception of Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 9027) and (ATCC 27853). These results suggest that E. pristis is a natural source of bioactive compounds for the search of new antibiotics which can be an interesting therapeutic approach to recover patients mainly infected by MRSA strains.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFernandes LS, da Costa YFG, de Bessa ME, Ferreira ALP, do Amaral Corrêa JO, et al. Metabolic profi ling and antibacterial activity of Eryngium pristis Cham. & Schltdl. - prospecting for its use in the treatment of bacterial infections. Arch Pharm Pharma Sci. 2021; 5: 020-028. DOI: 10.29328/journal.apps.1001027pt_PT
dc.identifier.doi10.29328/journal.apps.1001027pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/4676
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherHeighten Science Publications Incpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEryngium pristispt_PT
dc.subjectApiaceaept_PT
dc.subjectAnti bacterial activitypt_PT
dc.subjectBacterial resistancept_PT
dc.subjectStaphy lococcus aureuspt_PT
dc.subjectMethicillin-resistant Staphy lococcus aureuspt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleMetabolic profiling and antibacterial activity of Eryngium pristis Cham. & Schltdl. - prospecting for its use in the treatment of bacterial infectionspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage028pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage020pt_PT
oaire.citation.titleArchives of Pharmacy and Pharmaceutical Sciencespt_PT
oaire.citation.volume5pt_PT
person.familyNameCastilho
person.givenNamePaula C
person.identifierA-4412-2013
person.identifier.ciencia-id6D15-8C69-A2E0
person.identifier.orcid0000-0002-8303-4286
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd84fd917-438e-43bf-ac6f-256562481c05
relation.isAuthorOfPublication.latestForDiscoveryd84fd917-438e-43bf-ac6f-256562481c05

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