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Exploration of biomedical dendrimer space based on in-vitro physicochemical parameters: key factor analysis (Part 1)

2019Journal article Restricted access
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dc.contributor.authorMignani, Serge
dc.contributor.authorRodrigues, João
dc.contributor.authorRoy, René
dc.contributor.authorShi, Xiangyang
dc.contributor.authorCeña, Valentin
dc.contributor.authorEl Kazzouli, Saïd
dc.contributor.authorMajoral, Jean-Pierre
dc.date.accessioned2019-06-28T13:17:19Z
dc.date.available2019-06-28T13:17:19Z
dc.date.issued2019
dc.description.abstractDendrimers are highly branched, star-shaped macromolecules with nanometer-scale dimensions that can be readily modified with a range of functional groups, thus modifying their physicochemical and biological properties. In nanomedicine, dendrimers can be used as vectors for the targeted delivery strategy of a variety of biologically active agents or can be used as drug per se. In the future, it will be necessary to designate and develop 'safe' dendrimers, which is currently a crucial concern. Here, we analyze the key in vitro physicochemical parameters to be considered for preclinical evaluation of biomedical dendrimers.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMignani, S., Rodrigues, J., Roy, R., Shi, X., Ceña, V., El Kazzouli, S., & Majoral, J. P. (2019). Exploration of biomedical dendrimer space based on in-vivo physicochemical parameters: key factor analysis (Part 1). Drug discovery today.pt_PT
dc.identifier.doi10.1016/j.drudis.2019.02.014pt_PT
dc.identifier.issn1359-6446
dc.identifier.urihttp://hdl.handle.net/10400.13/2444
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationStrategic Project - UI 674 - 2014
dc.subjectBiomedical dendrimerpt_PT
dc.subjectDendrimerspt_PT
dc.subjectPhysicochemical parameterspt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleExploration of biomedical dendrimer space based on in-vitro physicochemical parameters: key factor analysis (Part 1)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 674 - 2014
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0674%2F2014/PT
oaire.citation.endPage1183pt_PT
oaire.citation.startPage1176pt_PT
oaire.citation.titleDrug Discovery Todaypt_PT
oaire.citation.volume24(5)pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMignani
person.familyNameRodrigues
person.familyNameRoy
person.familyNameShi
person.familyNameCeña
person.givenNameSerge
person.givenNameJoão
person.givenNameRené
person.givenNameXiangyang
person.givenNameValentin
person.identifier.ciencia-id8018-B5D2-6983
person.identifier.ciencia-idA81C-620E-DD6A
person.identifier.ciencia-idBA11-1437-B948
person.identifier.orcid0000-0002-1383-5256
person.identifier.orcid0000-0003-4552-1953
person.identifier.orcid0000-0001-5638-7302
person.identifier.orcid0000-0001-6785-6645
person.identifier.orcid0000-0001-8928-3681
person.identifier.ridB-6816-2008
person.identifier.ridA-1289-2007
person.identifier.ridL-1751-2017
person.identifier.scopus-author-id7003374430
person.identifier.scopus-author-id9233278800
person.identifier.scopus-author-id7402953116
person.identifier.scopus-author-id56269211900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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