Exploration of biomedical dendrimer space based on in-vitro physicochemical parameters: key factor analysis (Part 1)

Mignani, Serge; Rodrigues, João; Roy, René; Shi, Xiangyang; Ceña, Valentin; El Kazzouli, Saïd; Majoral, Jean-Pierre

http://hdl.handle.net/10400.13/2444

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Abstract(s)

Dendrimers are highly branched, star-shaped macromolecules with nanometer-scale dimensions that can be readily modified with a range of functional groups, thus modifying their physicochemical and biological properties. In nanomedicine, dendrimers can be used as vectors for the targeted delivery strategy of a variety of biologically active agents or can be used as drug per se. In the future, it will be necessary to designate and develop 'safe' dendrimers, which is currently a crucial concern. Here, we analyze the key in vitro physicochemical parameters to be considered for preclinical evaluation of biomedical dendrimers.

Keywords

Biomedical dendrimer Dendrimers Physicochemical parameters . Faculdade de Ciências Exatas e da Engenharia Centro de Química da Madeira

URI

http://hdl.handle.net/10400.13/2444

Citation

Mignani, S., Rodrigues, J., Roy, R., Shi, X., Ceña, V., El Kazzouli, S., & Majoral, J. P. (2019). Exploration of biomedical dendrimer space based on in-vivo physicochemical parameters: key factor analysis (Part 1). Drug discovery today.