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Re-exploring the high-throughput potential of microextraction techniques, SPME and MEPS, as powerful strategies for medical diagnostic purposes. Innovative approaches, recent applications and future trends

2014-03Journal article Restricted access
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dc.contributor.authorPereira, Jorge
dc.contributor.authorSilva, Catarina Luís
dc.contributor.authorPerestrelo, Rosa
dc.contributor.authorGonçalves, João
dc.contributor.authorAlves, Vera
dc.contributor.authorCâmara, José S.
dc.date.accessioned2019-07-19T09:20:13Z
dc.date.available2019-07-19T09:20:13Z
dc.date.issued2014-03
dc.description.abstractThe human population continues to grow exponentially in the fast developing and most populated countries, whereas in Western Europe it is getting older and older each year. This inevitably raises the demand for better and more efficient medical services without increasing the economic burden in the same proportion. To meet these requirements, improvement of medical diagnosis is certainly a key aspect to consider. Therefore, we need powerful analytical methodologies able to go deeper and further in the characterization of human metabolism and identification of disease biomarkers and endogenous molecules in body fluids and tissues. The ultimate goal is to have a reliable and early medical diagnosis, mitigating the disease complications as much as possible. Microextraction techniques (METs) represent a key step in these analytical methodologies by providing samples in the suitable volumes and purification levels necessary for the characterization of the target analytes. In this aspect, solid-phase microextraction (SPME) and, more recently, microextraction by packed sorbent (MEPS), are powerful sample preparation techniques, characterized by their reduced time of analysis, low solvent consumption, and broad application. Moreover, as miniaturized techniques, they can be easily automatized to have a high-throughput performance in the clinical environment. In this review, we explore some of the most interesting MEPS and SPME applications, focusing on recent trends and applications to medical diagnostic, particularly the in vivo and near real time applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPereira, J., Silva, C. L., Perestrelo, R., Gonçalves, J., Alves, V., & Câmara, J. S. (2014). Re-exploring the high-throughput potential of microextraction techniques, SPME and MEPS, as powerful strategies for medical diagnostic purposes. Innovative approaches, recent applications and future trends. Analytical and bioanalytical chemistry, 406(8), 2101-2122.pt_PT
dc.identifier.doi10.1007/s00216-013-7527-4pt_PT
dc.identifier.issn1618-2642
dc.identifier.urihttp://hdl.handle.net/10400.13/2485
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationStrategic Project - UI 674 - 2011-2012
dc.subjectMicro extraction techniquespt_PT
dc.subjectSolid-phase microextractionpt_PT
dc.subjectMicro extraction by packed sorbentpt_PT
dc.subjectMedical diagnosispt_PT
dc.subjectApplicationspt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleRe-exploring the high-throughput potential of microextraction techniques, SPME and MEPS, as powerful strategies for medical diagnostic purposes. Innovative approaches, recent applications and future trendspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 674 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0674%2F2011/PT
oaire.citation.endPage2122pt_PT
oaire.citation.startPage2101pt_PT
oaire.citation.titleAnalytical and Bioanalytical Chemistrypt_PT
oaire.citation.volume406(8)pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameAugusto Machado Pereira
person.familyNameSousa Luís
person.familyNamePerestrelo
person.familyNameGonçalves
person.familyNameAlves
person.familyNameCâmara
person.givenNameJorge
person.givenNameCatarina Grace
person.givenNameRosa
person.givenNameJoão
person.givenNameVera
person.givenNameJosé
person.identifierC-1300-2019
person.identifier1441319
person.identifierG-3003-2013
person.identifier.ciencia-idEC12-EE8F-50E8
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person.identifier.ciencia-id8C14-3188-9E44
person.identifier.ciencia-idE515-0AFA-CB1D
person.identifier.ciencia-id481C-08CE-90E5
person.identifier.orcid0000-0003-0316-5348
person.identifier.orcid0000-0002-3018-3165
person.identifier.orcid0000-0002-7223-1022
person.identifier.orcid0000-0002-1265-6686
person.identifier.orcid0000-0002-1485-6032
person.identifier.orcid0000-0003-1965-3151
person.identifier.ridI-2307-2014
person.identifier.ridC-1348-2019
person.identifier.scopus-author-id57194492726
person.identifier.scopus-author-id16686828800
person.identifier.scopus-author-id52163735200
person.identifier.scopus-author-id55792994000
person.identifier.scopus-author-id10140393000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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