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Toward male individualization with rapidly mutating y‐chromosomal short tandem repeats

2014Journal article Open access
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dc.contributor.authorBallantyne, Kaye N.
dc.contributor.authorRalf, Arwin
dc.contributor.authorAboukhalid, Rachid
dc.contributor.authorAchakzai, Niaz M.
dc.contributor.authorAnjos, Maria J.
dc.contributor.authorAyub, Qasim
dc.contributor.authorBalažic, Jože
dc.contributor.authorBallantyne, Jack
dc.contributor.authorBallard, David J.
dc.contributor.authorBerger, Burkhard
dc.contributor.authorBobillo, Cecilia
dc.contributor.authorBouabdellah, Mehdi
dc.contributor.authorBurri, Helen
dc.contributor.authorCapal, Tomas
dc.contributor.authorCaratti, Stefano
dc.contributor.authorCárdenas, Jorge
dc.contributor.authorCartault, François
dc.contributor.authorCarvalho, Elizeu F.
dc.contributor.authorCarvalho, Monica
dc.contributor.authorCheng, Baowen
dc.contributor.authorCoble, Michael D.
dc.contributor.authorComas, David
dc.contributor.authorCorach, Daniel
dc.contributor.authorD'Amato, Maria E.
dc.contributor.authorDavison, Sean
dc.contributor.authorde Knijff, Peter
dc.contributor.authorDe Ungria, Maria Corazon A.
dc.contributor.authorDecorte, Ronny
dc.contributor.authorDobosz, Tadeusz
dc.contributor.authorDupuy, Berit M.
dc.contributor.authorElmrghni, Samir
dc.contributor.authorGliwiński, Mateusz
dc.contributor.authorGomes, Sara C.
dc.contributor.authorGrol, Laurens
dc.contributor.authorHaas, Cordula
dc.contributor.authorHanson, Erin
dc.contributor.authorHenke, Jürgen
dc.contributor.authorHenke, Lotte
dc.contributor.authorHerrera-Rodríguez, Fabiola
dc.contributor.authorHill, Carolyn R.
dc.contributor.authorHolmlund, Gunilla
dc.contributor.authorHonda, Katsuya
dc.contributor.authorImmel, Uta-Dorothee
dc.contributor.authorInokuchi, Shota
dc.contributor.authorJobling, Mark A.
dc.contributor.authorKaddura, Mahmoud
dc.contributor.authorKim, Jong S.
dc.contributor.authorKim, Soon H.
dc.contributor.authorKim, Wook
dc.contributor.authorKing, Turi E.
dc.contributor.authorKlausriegler, Eva
dc.contributor.authorKling, Daniel
dc.contributor.authorKovačević, Lejla
dc.contributor.authorKovatsi, Leda
dc.contributor.authorKrajewski, Paweł
dc.contributor.authorKravchenko, Sergey
dc.contributor.authorLarmuseau, Maarten H. D.
dc.contributor.authorLee, Eun Young
dc.contributor.authorLessig, Ruediger
dc.contributor.authorLivshits, Ludmila A.
dc.contributor.authorMarjanović, Damir
dc.contributor.authorMinarik, Marek
dc.contributor.authorMizuno, Natsuko
dc.contributor.authorMoreira, Helena
dc.contributor.authorMorling, Niels
dc.contributor.authorMukherjee, Meeta
dc.contributor.authorMunier, Patrick
dc.contributor.authorNagaraju, Javaregowda
dc.contributor.authorNeuhuber, Franz
dc.contributor.authorNie, Shengjie
dc.contributor.authorNilasitsataporn, Premlaphat
dc.contributor.authorNishi, Takeki
dc.contributor.authorOh, Hye H.
dc.contributor.authorOlofsson, Jill
dc.contributor.authorOnofri, Valerio
dc.contributor.authorPalo, Jukka U.
dc.contributor.authorPamjav, Horolma
dc.contributor.authorParson, Walther
dc.contributor.authorPetlach, Michal
dc.contributor.authorPhillips, Christopher
dc.contributor.authorPloski, Rafal
dc.contributor.authorPrasad, Samayamantri P. R.
dc.contributor.authorPrimorac, Dragan
dc.contributor.authorPurnomo, Gludhug A.
dc.contributor.authorPurps, Josephine
dc.contributor.authorRangel-Villalobos, Hector
dc.contributor.authorRębała, Krzysztof
dc.contributor.authorRerkamnuaychoke, Budsaba
dc.contributor.authorGonzalez, Danel Rey
dc.contributor.authorRobino, Carlo
dc.contributor.authorRoewer, Lutz
dc.contributor.authorRosa, Alexandra
dc.contributor.authorSajantila, Antti
dc.contributor.authorSala, Andrea
dc.contributor.authorSalvador, Jazelyn M.
dc.contributor.authorSanz, Paula
dc.contributor.authorSchmitt, Cornelia
dc.contributor.authorSharma, Anil K.
dc.contributor.authorSilva, Dayse A.
dc.contributor.authorShin, Kyoung-Jin
dc.contributor.authorSijen, Titia
dc.contributor.authorSirker, Miriam
dc.contributor.authorSiváková, Daniela
dc.contributor.authorŠkaro, Vedrana
dc.contributor.authorSolano-Matamoros, Carlos
dc.contributor.authorSouto, Luis
dc.contributor.authorStenzl, Vlastimil
dc.contributor.authorSudoyo, Herawati
dc.contributor.authorSyndercombe-Court, Denise
dc.contributor.authorTagliabracci, Adriano
dc.contributor.authorTaylor, Duncan
dc.contributor.authorTillmar, Andreas
dc.contributor.authorTsybovsky, Iosif S.
dc.contributor.authorTyler-Smith, Chris
dc.contributor.authorvan der Gaag, Kristiaan J.
dc.contributor.authorVanek, Daniel
dc.contributor.authorVölgyi, Antónia
dc.contributor.authorWard, Denise
dc.contributor.authorWillemse, Patricia
dc.contributor.authorYap, Eric P.H.
dc.contributor.authorYong, Rita Y.Y.
dc.contributor.authorPajnič, Irena Zupanič
dc.contributor.authorKayser, Manfred
dc.date.accessioned2022-03-07T11:26:04Z
dc.date.available2022-03-07T11:26:04Z
dc.date.issued2014
dc.description.abstractRelevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are com monly used for testing close paternal relationships among individuals and populations, and for male lineage iden tification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strik ingly, >99% of the 12,272 unrelated males were com pletely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99836–0.9999988). Haplotype sharing between populations was almost ab sent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in ur ban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 father–son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and over all male relative differentiation was raised by 23.5%. Our study demonstrates the value of RM Y-STRs in identifying and separating unrelated and related males and provides a reference database.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBallantyne, K. N., Ralf, A., Aboukhalid, R., Achakzai, N. M., Anjos, M. J., Ayub, Q., ... & Kayser, M. (2014). Toward male individualization with rapidly mutating y‐chromosomal short tandem repeats. https://doi.org/10.1002/humu.22599, 35(8), 1021-1032. https://doi.org/10.1002/humu.22599pt_PT
dc.identifier.doi10.1002/humu.22599pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/4118
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectY-chromosomept_PT
dc.subjectY-STRspt_PT
dc.subjectHaplotypespt_PT
dc.subjectRM YSTRspt_PT
dc.subjectPaternal lineagept_PT
dc.subjectForensicpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências da Vidapt_PT
dc.titleToward male individualization with rapidly mutating y‐chromosomal short tandem repeatspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1032pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage1021pt_PT
oaire.citation.titleHuman Mutationpt_PT
oaire.citation.volume35pt_PT
person.familyNameda Silva Rosa
person.givenNamePatrícia Alexandra
person.identifier.ciencia-idF01B-3B5B-2269
person.identifier.orcid0000-0002-1827-6828
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcc0e7b32-45ac-4aad-9256-32bc9de21975
relation.isAuthorOfPublication.latestForDiscoverycc0e7b32-45ac-4aad-9256-32bc9de21975

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