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Antitumor efficacy of doxorubicin encapsulated within PEGylated poly(amidoamine) dendrimers

2014Journal article Restricted access
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dc.contributor.authorLiao, Huihui
dc.contributor.authorLiu, Hui
dc.contributor.authorLi, Yulin
dc.contributor.authorZhang, Mengen
dc.contributor.authorTomás, Helena
dc.contributor.authorShen, Mingwu
dc.contributor.authorShi, Xiangyang
dc.date.accessioned2019-07-09T15:16:23Z
dc.date.available2019-07-09T15:16:23Z
dc.date.issued2014
dc.description.abstractWe report here a general approach to using poly(amidoamine) (PAMAM) dendrimers modified with polyethylene glycol (PEG) as a platform to encapsulate an anticancer drug doxorubicin (DOX) for in vitro cancer therapy applications. In this approach, PEGylated PAMAM dendrimers were synthesized by conjugating monomethoxypolyethylene glycol with carboxylic acid end group (mPEG-COOH) onto the surface of generation 5 amine-terminated PAMAM dendrimer (G5.NH2), followed by acetylation of the remaining dendrimer terminal amines. By varying the molar ratios of mPEG-COOH/G5.NH2, G5.NHAc-mPEGn (n55, 10, 20, and 40, respectively) with different PEGylation degrees were obtained. We show that the PEGylated dendrimers are able to encapsulate DOX with approximately similar loading capacity regardless of the PEGylation degree. The formed dendrimer/DOX complexes are water soluble and stable. In vitro release studies show that DOX complexed with the PEGylated dendrimers can be released in a sustained manner. Further cell viability assay in conjunction with cell morphology observation demonstrates that the G5.NHAc-mPEGn/DOX complexes display effective antitumor activity, and the DOX molecules encapsulated within complexes can be internalized into the cell nucleus, similar to the free DOX drug. Findings from this study suggest that PEGylated dendrimers may be used as a general drug carrier to encapsulate various hydrophobic drugs for different therapeutic applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLiao, H., Liu, H., Li, Y., Zhang, M., Tomás, H., Shen, M., & Shi, X. (2014). Antitumor efficacy of doxorubicin encapsulated within PEGylated poly (amidoamine) dendrimers. Journal of Applied Polymer Science, 131(11).pt_PT
dc.identifier.doi10.1002/app.40358pt_PT
dc.identifier.issn0021-8995
dc.identifier.urihttp://hdl.handle.net/10400.13/2470
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationDENDIMAGE - Development of Novel Dendrimer-Based Nanoparticles for Dual Mode Computed Tomography and Magnetic Resonance Imaging of Tumors
dc.relationSelf-assembled nanoparticles based on PEG-PLA-dendrimer building blocks for dual gene/drug delivery
dc.relationStrategic Project - UI 674 - 2011-2012
dc.subjectDendrimerspt_PT
dc.subjectHyperbranched polymers and macrocyclespt_PT
dc.subjectDrug delivery systemspt_PT
dc.subjectNanoparticlespt_PT
dc.subjectNanowirespt_PT
dc.subjectNanocrystalspt_PT
dc.subjectDoxorubicinpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleAntitumor efficacy of doxorubicin encapsulated within PEGylated poly(amidoamine) dendrimerspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDENDIMAGE - Development of Novel Dendrimer-Based Nanoparticles for Dual Mode Computed Tomography and Magnetic Resonance Imaging of Tumors
oaire.awardTitleSelf-assembled nanoparticles based on PEG-PLA-dendrimer building blocks for dual gene/drug delivery
oaire.awardTitleStrategic Project - UI 674 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCTM-NAN%2F1748%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCTM-NAN%2F116788%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0674%2F2011/PT
oaire.citation.endPage10pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleJournal of Applied Polymer Sciencept_PT
oaire.citation.volume131(11)pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameLi
person.familyNameTomás
person.familyNameShi
person.givenNameYulin
person.givenNameHelena
person.givenNameXiangyang
person.identifier556975
person.identifier.ciencia-id4D14-D31E-A8BE
person.identifier.ciencia-idBA11-1437-B948
person.identifier.orcid0000-0001-5569-1038
person.identifier.orcid0000-0002-7856-2041
person.identifier.orcid0000-0001-6785-6645
person.identifier.ridA-4082-2013
person.identifier.ridE-5991-2010
person.identifier.ridA-1289-2007
person.identifier.scopus-author-id55718977200
person.identifier.scopus-author-id6508104177
person.identifier.scopus-author-id7402953116
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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