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Genetic characterization of Guinea-Bissau using a 12 X-chromosomal STR system: inferences from a multiethnic population

2017Journal article Open access
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dc.contributor.authorGomes, Iva
dc.contributor.authorPereira, Plácido J.P.
dc.contributor.authorHarms, Sonja
dc.contributor.authorOliveira, Andréa M.
dc.contributor.authorSchneider, Peter M.
dc.contributor.authorBrehm, António
dc.date.accessioned2020-11-13T11:54:14Z
dc.date.available2020-11-13T11:54:14Z
dc.date.issued2017
dc.description.abstractA male West African sample from Guinea-Bissau (West-African coast) was genetically analyzed using 12 X chromosomal short tandem repeats that are grouped into four haplotype groups. Linkage disequilibrium was tested (p ≤ 0.0008) and association was detected for the majority of markers in three out of the four studied haplotype clusters. The sample of 332 unrelated individuals analyzed in this study belonged to several recognized ethnic groups (n = 18) which were used to evaluate the genetic variation of Guinea-Bissau’s population. Pairwise genetic distances (FST) did not reveal significant differences among the majority of groups. An additional 110 samples from other countries also belonging to West Africa were as well compared with the sample of Guinea-Bissau. No significant differences were found between these two groups of West African individuals, supporting the genetic homogeneity of this region on the X chromosome level. The generation of over 100 DNA West African sequences provided new insights into the repeat sequence structure of some of the present X-STRs. Parameters for forensic evaluation were also calculated for each X-STR, supporting the potential application of these markers in typical kinship scenarios. Also, the high power of discrimination values for samples of female and male origin observed in this study, confirms the usefulness of the present X-STRs in identification analysis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGomes, I., Pereira, P. J., Harms, S., Oliveira, A. M., Schneider, P. M., & Brehm, A. (2017). Genetic characterization of Guinea-Bissau using a 12 X-chromosomal STR system: inferences from a multiethnic population. Forensic Science International: Genetics, 31, 89-94.pt_PT
dc.identifier.doi10.1016/j.fsigen.2017.08.016pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/2976
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectGuinea-Bissaupt_PT
dc.subjectWest Africapt_PT
dc.subjectX- STRspt_PT
dc.subjectInvestigator Argus X-12pt_PT
dc.subjectForensic geneticspt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências da Vidapt_PT
dc.titleGenetic characterization of Guinea-Bissau using a 12 X-chromosomal STR system: inferences from a multiethnic populationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage94pt_PT
oaire.citation.startPage89pt_PT
oaire.citation.titleForensic Science International: Geneticspt_PT
oaire.citation.volume31pt_PT
person.familyNameBrehm
person.givenNameAntonio
person.identifier.ciencia-id3613-8D1F-0EDF
person.identifier.orcid0000-0003-3168-5340
person.identifier.scopus-author-idAuthor ID 7006085833
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication62d279e2-247a-4652-a370-3e8c2a846e31
relation.isAuthorOfPublication.latestForDiscovery62d279e2-247a-4652-a370-3e8c2a846e31

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