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Complexing methylene blue with phosphorus dendrimers to increase photodynamic activity

2017Journal article Open access
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dc.contributor.authorDabrzalska, Monika
dc.contributor.authorJanaszewska, Anna
dc.contributor.authorZablocka, Maria
dc.contributor.authorMignani, Serge
dc.contributor.authorMajoral, Jean
dc.contributor.authorKlajnert-Maculewicz, Barbara
dc.date.accessioned2024-02-28T16:13:02Z
dc.date.available2024-02-28T16:13:02Z
dc.date.issued2017
dc.description.abstractThe efficiency of photodynamic therapy is limited mainly due to low selectivity, unfavorable biodistribution of photosensitizers, and long-lasting skin sensitivity to light. However, drug delivery systems based on nanoparticles may overcome the limitations mentioned above. Among others, dendrimers are particularly attractive as carriers, because of their globular architecture and high loading capacity. The goal of the study was to check whether an anionic phosphorus dendrimer is suitable as a carrier of a photosensitizer—methylene blue (MB). As a biological model, basal cell carcinoma cell lines were used. We checked the influence of the MB complexation on its singlet oxygen production ability using a commercial fluorescence probe. Next, cellular uptake, phototoxicity, reactive oxygen species (ROS) generation, and cell death were investigated. The MB-anionic dendrimer complex (MB-1an) was found to generate less singlet oxygen; however, the complex showed higher cellular uptake and phototoxicity against basal cell carcinoma cell lines, which was accompanied with enhanced ROS production. Owing to the obtained results, we conclude that the photodynamic activity of MB complexed with an anionic dendrimer is higher than free MB against basal cell carcinoma cell lines.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDabrzalska, M., Janaszewska, A., Zablocka, M., Mignani, S., Majoral, J. P., & Klajnert-Maculewicz, B. (2017). Complexing methylene blue with phosphorus dendrimers to increase photodynamic activity. Molecules, 22(3), 345.pt_PT
dc.identifier.doi10.3390/molecules22030345pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/5590
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMethylene bluept_PT
dc.subjectPhosphorus dendrimerpt_PT
dc.subjectNanocarrierpt_PT
dc.subjectPhotosensitizerpt_PT
dc.subjectPhotodynamic therapypt_PT
dc.subjectPhototoxicitypt_PT
dc.subjectBasal cell carcinomapt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.titleComplexing methylene blue with phosphorus dendrimers to increase photodynamic activitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue3pt_PT
oaire.citation.startPage345pt_PT
oaire.citation.titleMoleculespt_PT
oaire.citation.volume22pt_PT
person.familyNameMignani
person.givenNameSerge
person.identifier.ciencia-id8018-B5D2-6983
person.identifier.orcid0000-0002-1383-5256
person.identifier.scopus-author-id7003374430
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcabd0aa0-5827-4e97-889b-922136d2dd4b
relation.isAuthorOfPublication.latestForDiscoverycabd0aa0-5827-4e97-889b-922136d2dd4b

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