Repository logo
 
Publication

Neutral high-generation phosphorus dendrimers inhibit macrophage-mediated inflammatory response in vitro and in vivo

2017Journal article Open access
Simple item page
dc.contributor.authorPosadas, I.
dc.contributor.authorRomero-Castillo, L.
dc.contributor.authorEl Brahmi, N.
dc.contributor.authorManzanares, D.
dc.contributor.authorMignani, S.
dc.contributor.authorMajoral, J.-P.
dc.contributor.authorCeña, V.
dc.date.accessioned2024-02-28T15:50:14Z
dc.date.available2024-02-28T15:50:14Z
dc.date.issued2017
dc.description.abstractInflammation is part of the physiological response of the organism to infectious diseases caused by organisms such as bacteria, viruses, fungi, or parasites. Innate immunity, mediated by mono nuclear phagocytes, including monocytes and macrophages, is a first line of defense against infectious diseases and plays a key role triggering the delayed adaptive response that ensures an efficient defense against pathogens. Monocytes and macrophages stimu lation by pathogen antigens results in activation of different signaling pathways leading to the release of proinflammatory cyto kines. However, inflammation can also participate in the pathogenesis of several diseases, the autoimmune diseases that represent a relevant burden for human health. Dendrimers are branched, multivalent nanoparticles with a well-defined structure that have a high potential for biomedical applications. To explore new approaches to fight against the negative aspects of inflammation, we have used neutral high-generation phosphorus dendrimers bearing 48 (G3) or 96 (G4) bisphosphonate groups on their surface. These dendrimers show no toxicity and have good solubility and chemical stability in aqueous solutions. Here, we present data indicating that neutral phosphorus dendrimers show impressive antiinflammatory activities both in vitro and in vivo. In vitro, these dendrimers reduced the secretion of proinflammatory cytokines from mice and human monocyte derived macrophages. In addition, these molecules present efficient antiinflammatory activity in vivo in a mouse model of subchronic inflammation. Taken together, these data suggest that neutral G3- G4 phosphorus dendrimers have strong potential applications in the therapy of inflammation and, likely, of autoimmune diseases.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPosadas, I., Romero-Castillo, L., El Brahmi, N., Manzanares, D., Mignani, S., Majoral, J. P., & Ceña, V. (2017). Neutral high-generation phosphorus dendrimers inhibit macrophage-mediated inflammatory response in vitro and in vivo. Proceedings of the National Academy of Sciences, 114(37), E7660-E7669.pt_PT
dc.identifier.doi10.1073/pnas.1704858114pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/5589
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNational Academy of Sciencespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectDendrimerspt_PT
dc.subjectInflammationpt_PT
dc.subjectInnate immunitypt_PT
dc.subjectAir pouchpt_PT
dc.subjectMacrophagept_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.titleNeutral high-generation phosphorus dendrimers inhibit macrophage-mediated inflammatory response in vitro and in vivopt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue37pt_PT
oaire.citation.titleProceedings of the National Academy of Sciencespt_PT
oaire.citation.volume114pt_PT
person.familyNameMignani
person.givenNameSerge
person.identifier.ciencia-id8018-B5D2-6983
person.identifier.orcid0000-0002-1383-5256
person.identifier.scopus-author-id7003374430
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcabd0aa0-5827-4e97-889b-922136d2dd4b
relation.isAuthorOfPublication.latestForDiscoverycabd0aa0-5827-4e97-889b-922136d2dd4b

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Neutral high-generation phosphorus dendrimers inhibit macrophage-mediated inflammatory response in vitro and in vivo.pdf
Size:
1.49 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artigos em revistas internacionais