Loading...
Publication
Neutral high-generation phosphorus dendrimers inhibit macrophage-mediated inflammatory response in vitro and in vivo
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 1.49 MB | Adobe PDF |
Advisor(s)
Abstract(s)
Inflammation is part of the physiological response of the organism
to infectious diseases caused by organisms such as bacteria,
viruses, fungi, or parasites. Innate immunity, mediated by mono nuclear phagocytes, including monocytes and macrophages, is a
first line of defense against infectious diseases and plays a key role
triggering the delayed adaptive response that ensures an efficient
defense against pathogens. Monocytes and macrophages stimu lation by pathogen antigens results in activation of different
signaling pathways leading to the release of proinflammatory cyto kines. However, inflammation can also participate in the pathogenesis
of several diseases, the autoimmune diseases that represent a relevant
burden for human health. Dendrimers are branched, multivalent
nanoparticles with a well-defined structure that have a high potential
for biomedical applications. To explore new approaches to fight
against the negative aspects of inflammation, we have used neutral
high-generation phosphorus dendrimers bearing 48 (G3) or 96 (G4)
bisphosphonate groups on their surface. These dendrimers show no
toxicity and have good solubility and chemical stability in aqueous
solutions. Here, we present data indicating that neutral phosphorus
dendrimers show impressive antiinflammatory activities both in
vitro and in vivo. In vitro, these dendrimers reduced the secretion
of proinflammatory cytokines from mice and human monocyte derived macrophages. In addition, these molecules present efficient
antiinflammatory activity in vivo in a mouse model of subchronic
inflammation. Taken together, these data suggest that neutral G3-
G4 phosphorus dendrimers have strong potential applications in the
therapy of inflammation and, likely, of autoimmune diseases.
Description
Keywords
Dendrimers Inflammation Innate immunity Air pouch Macrophage . Faculdade de Ciências Exatas e da Engenharia
Citation
Posadas, I., Romero-Castillo, L., El Brahmi, N., Manzanares, D., Mignani, S., Majoral, J. P., & Ceña, V. (2017). Neutral high-generation phosphorus dendrimers inhibit macrophage-mediated inflammatory response in vitro and in vivo. Proceedings of the National Academy of Sciences, 114(37), E7660-E7669.
Publisher
National Academy of Sciences