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Gelatin-based ballistic gel formulated with phytosynthesized nanocellulose from Arundo donax for alpha-amylase enzyme inhibition activity
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Advisor(s)
Abstract(s)
Arundo donax, an indigenous plant in the Mediterranean region, has affected the growth of native vegetation as
an invasive plant, ultimately reducing soil quality and affecting the food chain in several areas of the world.
Thus, the present work aims to obtain cellulose from the A. donax leaf extract via organosolv fractionation and
bleaching method, followed by centrifugal fractionation to yield nanocellulose of moderately monodispersed
(0.428 PDI) 91.2 nm in size and a zeta potential of -35.5 mV of high stability in aqueous medium (water). In
addition, the resultant nanocellulose was formulated in ballistic gelatin hydrogel, and their antidiabetic effect via
alpha-amylase enzyme inhibition activity was also investigated. Systematic characterization of the hydrogel
samples (different volume ratios of gelatin and nanocellulose) revealed that the sample with 18:2 (v/v) gelatin:
nanocellulose content is thermally stable until 152 ◦C, releasing nanocellulose for three days from hydrogel until
45 ◦C. This study confirms the feasibility and potential of utilizing invasive plant species to extract nanocellulose
for medical purposes. Furthermore, the gelatin-formulated nanocellulose, with its demonstrated alpha-amylase
inhibition activity at a dosage of 80 µg/mL, holds the promise of being a potential revolutionary medical
gummy for sustained reduction of blood glucose levels.
Description
Keywords
Invasive plant Nanocellulose Hydrogel Antidiabetic activity Amylase inhibition . - Centro de Química da Madeira Faculdade de Ciências Exatas e da Engenharia
Citation
Jeevanandam, J., Castro, R., & Rodrigues, J. (2024). Gelatin-based ballistic gel formulated with phytosynthesized nanocellulose from Arundo donax for alpha-amylase enzyme inhibition activity. Carbohydrate Polymer Technologies and Applications, 8, 100575.
Publisher
Elsevier