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Gelatin-based ballistic gel formulated with phytosynthesized nanocellulose from Arundo donax for alpha-amylase enzyme inhibition activity

2024-12Journal article Open access
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datacite.subject.fosCiências Agrárias::Biotecnologia Agrária e Alimentar
datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.fosEngenharia e Tecnologia::Engenharia Química
dc.contributor.authorJeevanandam, Jaison
dc.contributor.authorCastro, Rita
dc.contributor.authorRodrigues, João
dc.contributor.authorCastro, Rita
dc.contributor.authorRodrigues, João
dc.date.accessioned2025-05-29T12:55:09Z
dc.date.available2025-05-29T12:55:09Z
dc.date.issued2024-12
dc.description.abstractArundo donax, an indigenous plant in the Mediterranean region, has affected the growth of native vegetation as an invasive plant, ultimately reducing soil quality and affecting the food chain in several areas of the world. Thus, the present work aims to obtain cellulose from the A. donax leaf extract via organosolv fractionation and bleaching method, followed by centrifugal fractionation to yield nanocellulose of moderately monodispersed (0.428 PDI) 91.2 nm in size and a zeta potential of -35.5 mV of high stability in aqueous medium (water). In addition, the resultant nanocellulose was formulated in ballistic gelatin hydrogel, and their antidiabetic effect via alpha-amylase enzyme inhibition activity was also investigated. Systematic characterization of the hydrogel samples (different volume ratios of gelatin and nanocellulose) revealed that the sample with 18:2 (v/v) gelatin: nanocellulose content is thermally stable until 152 ◦C, releasing nanocellulose for three days from hydrogel until 45 ◦C. This study confirms the feasibility and potential of utilizing invasive plant species to extract nanocellulose for medical purposes. Furthermore, the gelatin-formulated nanocellulose, with its demonstrated alpha-amylase inhibition activity at a dosage of 80 µg/mL, holds the promise of being a potential revolutionary medical gummy for sustained reduction of blood glucose levels.eng
dc.identifier.citationJeevanandam, J., Castro, R., & Rodrigues, J. (2024). Gelatin-based ballistic gel formulated with phytosynthesized nanocellulose from Arundo donax for alpha-amylase enzyme inhibition activity. Carbohydrate Polymer Technologies and Applications, 8, 100575.
dc.identifier.doi10.1016/j.carpta.2024.100575
dc.identifier.issn2666-8939
dc.identifier.urihttp://hdl.handle.net/10400.13/7293
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationMadeira Chemistry Research Centre
dc.relation.ispartofCarbohydrate Polymer Technologies and Applications
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectInvasive plant
dc.subjectNanocellulose
dc.subjectHydrogel
dc.subjectAntidiabetic activity
dc.subjectAmylase inhibition
dc.subject.
dc.subject- Centro de Química da Madeira
dc.subjectFaculdade de Ciências Exatas e da Engenharia
dc.titleGelatin-based ballistic gel formulated with phytosynthesized nanocellulose from Arundo donax for alpha-amylase enzyme inhibition activityeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00674%2F2020/PT
oaire.citation.titleCarbohydrate Polymer Technologies and Applications
oaire.citation.volume8
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCastro
person.familyNameRodrigues
person.givenNameRita
person.givenNameJoão
person.identifier.ciencia-id8314-881E-4986
person.identifier.ciencia-idA81C-620E-DD6A
person.identifier.orcid0000-0002-9337-062X
person.identifier.orcid0000-0003-4552-1953
person.identifier.ridA-2497-2013
person.identifier.ridB-6816-2008
person.identifier.scopus-author-id9233278800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublicationceb211d0-5522-42ba-bbf0-adfc23f37f84
relation.isAuthorOfPublication53031fca-b2e7-4ce4-bda9-61e486da4547
relation.isAuthorOfPublication.latestForDiscoveryceb211d0-5522-42ba-bbf0-adfc23f37f84
relation.isProjectOfPublicatione30e13d9-be9a-4f34-91ea-a1682abce74e
relation.isProjectOfPublication.latestForDiscoverye30e13d9-be9a-4f34-91ea-a1682abce74e

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