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Publication
Gas foaming of electrospun poly(L-lactide-co-caprolactone)/silk fibroin nanofiber scaffolds to promote cellular infiltration and tissue regeneration
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Advisor(s)
Abstract(s)
Electrospun nanofibers emulate extracellular matrix (ECM) morphology and architecture; however, small pore
size and tightly-packed fibers impede their translation in tissue engineering. Here we exploited in situ gas
foaming to afford three-dimensional (3D) poly(L-lactide-co-ε-caprolactone)/silk fibroin (PLCL/SF) scaffolds,
which exhibited nanotopographic cues and a multilayered structure. The addition of SF improved the hydro philicity and biocompatibility of 3D PLCL scaffolds. Three-dimensional scaffolds exhibited larger pore size (38.75
± 9.78 μm2
) and high porosity (87.1% ± 1.5%) than that of their 2D counterparts. 3D scaffolds also improved the
deposition of ECM components and neo-vessel regeneration as well as exhibited more numbers of CD163+/
CCR7+ cells after 2 weeks implantation in a subcutaneous model. Collectively, 3D PLCL/SF scaffolds have broad
implications for regenerative medicine and tissue engineering applications.
Description
Keywords
Electrospun nanofiber scaffold Gas foaming Three-dimensional scaffolds Cell infiltration Tissue engineering . Faculdade de Ciências Exatas e da Engenharia Centro de Química da Madeira
Citation
Chen, Y., Jia, Z., Shafiq, M., Xie, X., Xiao, X., Castro, R., ... & Mo, X. (2021). Gas foaming of electrospun poly (L-lactide-co-caprolactone)/silk fibroin nanofiber scaffolds to promote cellular infiltration and tissue regeneration. Colloids and Surfaces B: Biointerfaces, 201, 111637. https://doi.org/10.1016/j.colsurfb.2021.111637
Publisher
Elsevier