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Gas foaming of electrospun poly(L-lactide-co-caprolactone)/silk fibroin nanofiber scaffolds to promote cellular infiltration and tissue regeneration

2021Journal article Open access
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dc.contributor.authorChen, Yujie
dc.contributor.authorJia, Zihao
dc.contributor.authorShafiq, Muhammad
dc.contributor.authorXie, Xianrui
dc.contributor.authorXiao, Xianghao
dc.contributor.authorCastro, Rita
dc.contributor.authorRodrigues, João
dc.contributor.authorWu, Jinglei
dc.contributor.authorZhou, Guangdong
dc.contributor.authorMo, Xiumei
dc.date.accessioned2022-02-18T11:11:02Z
dc.date.available2022-02-18T11:11:02Z
dc.date.issued2021
dc.description.abstractElectrospun nanofibers emulate extracellular matrix (ECM) morphology and architecture; however, small pore size and tightly-packed fibers impede their translation in tissue engineering. Here we exploited in situ gas foaming to afford three-dimensional (3D) poly(L-lactide-co-ε-caprolactone)/silk fibroin (PLCL/SF) scaffolds, which exhibited nanotopographic cues and a multilayered structure. The addition of SF improved the hydro philicity and biocompatibility of 3D PLCL scaffolds. Three-dimensional scaffolds exhibited larger pore size (38.75 ± 9.78 μm2 ) and high porosity (87.1% ± 1.5%) than that of their 2D counterparts. 3D scaffolds also improved the deposition of ECM components and neo-vessel regeneration as well as exhibited more numbers of CD163+/ CCR7+ cells after 2 weeks implantation in a subcutaneous model. Collectively, 3D PLCL/SF scaffolds have broad implications for regenerative medicine and tissue engineering applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationChen, Y., Jia, Z., Shafiq, M., Xie, X., Xiao, X., Castro, R., ... & Mo, X. (2021). Gas foaming of electrospun poly (L-lactide-co-caprolactone)/silk fibroin nanofiber scaffolds to promote cellular infiltration and tissue regeneration. Colloids and Surfaces B: Biointerfaces, 201, 111637. https://doi.org/10.1016/j.colsurfb.2021.111637pt_PT
dc.identifier.doi10.1016/j.colsurfb.2021.111637pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/4091
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationMadeira Chemistry Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectElectrospun nanofiber scaffoldpt_PT
dc.subjectGas foamingpt_PT
dc.subjectThree-dimensional scaffoldspt_PT
dc.subjectCell infiltrationpt_PT
dc.subjectTissue engineeringpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleGas foaming of electrospun poly(L-lactide-co-caprolactone)/silk fibroin nanofiber scaffolds to promote cellular infiltration and tissue regenerationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00674%2F2020/PT
oaire.citation.startPage111637pt_PT
oaire.citation.titleColloids and Surfaces B: Biointerfacespt_PT
oaire.citation.volume201pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCastro
person.familyNameRodrigues
person.givenNameRita
person.givenNameJoão
person.identifier.ciencia-id8314-881E-4986
person.identifier.ciencia-idA81C-620E-DD6A
person.identifier.orcid0000-0002-9337-062X
person.identifier.orcid0000-0003-4552-1953
person.identifier.ridA-2497-2013
person.identifier.ridB-6816-2008
person.identifier.scopus-author-id9233278800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationceb211d0-5522-42ba-bbf0-adfc23f37f84
relation.isAuthorOfPublication53031fca-b2e7-4ce4-bda9-61e486da4547
relation.isAuthorOfPublication.latestForDiscoveryceb211d0-5522-42ba-bbf0-adfc23f37f84
relation.isProjectOfPublicatione30e13d9-be9a-4f34-91ea-a1682abce74e
relation.isProjectOfPublication.latestForDiscoverye30e13d9-be9a-4f34-91ea-a1682abce74e

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