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Cortical gyrification morphology in individuals with ASD and ADHD across the lifespan: a systematic review and meta-analysis
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Orientador(es)
Resumo(s)
Autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) are common neurodevelopmental
disorders (NDDs) that may impact brain maturation. A number of studies have examined cortical gyrification morphology
in both NDDs. Here we review and when possible pool their results to better understand the shared and potentially
disorder-specific gyrification features. We searched MEDLINE, PsycINFO, and EMBASE databases, and 24 and 10 studies met
the criteria to be included in the systematic review and meta-analysis portions, respectively. Meta-analysis of local
Gyrification Index (lGI) findings across ASD studies was conducted with SDM software adapted for surface-based
morphometry studies. Meta-regressions were used to explore effects of age, sex, and sample size on gyrification
differences. There were no significant differences in gyrification across groups. Qualitative synthesis of remaining ASD
studies highlighted heterogeneity in findings. Large-scale ADHD studies reported no differences in gyrification between cases and controls suggesting that, similar to ASD, there is currently no evidence of differences in gyrification morphology
compared with controls. Larger, longitudinal studies are needed to further clarify the effects of age, sex, and IQ on cortical
gyrification in these NDDs.
Descrição
Palavras-chave
Attention-deficit hyperactivity disorder Autism spectrum disorder Cortical gyrification lGI Structural MRI . Faculdade de Ciências da Vida
Contexto Educativo
Citação
Gharehgazlou, A., Freitas, C., Ameis, S. H., Taylor, M. J., Lerch, J. P., Radua, J., & Anagnostou, E. (2021). Cortical gyrification morphology in individuals with ASD and ADHD across the lifespan: a systematic review and meta-analysis. Cerebral Cortex, 31(5), 2653-2669. doi: 10.1093/cercor/bhaa381
Editora
Oxford University Press