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Cortical gyrification morphology in individuals with ASD and ADHD across the lifespan: a systematic review and meta-analysis

2021Journal article Open access
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dc.contributor.authorGharehgazlou, Avideh
dc.contributor.authorFreitas, Carina
dc.contributor.authorAmeis, Stephanie H
dc.contributor.authorTaylor, Margot J.
dc.contributor.authorLerch, Jason P.
dc.contributor.authorRadua, Joaquim
dc.contributor.authorAnagnostou, Evdokia
dc.date.accessioned2022-06-09T11:08:31Z
dc.date.available2022-06-09T11:08:31Z
dc.date.issued2021
dc.description.abstractAutism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) are common neurodevelopmental disorders (NDDs) that may impact brain maturation. A number of studies have examined cortical gyrification morphology in both NDDs. Here we review and when possible pool their results to better understand the shared and potentially disorder-specific gyrification features. We searched MEDLINE, PsycINFO, and EMBASE databases, and 24 and 10 studies met the criteria to be included in the systematic review and meta-analysis portions, respectively. Meta-analysis of local Gyrification Index (lGI) findings across ASD studies was conducted with SDM software adapted for surface-based morphometry studies. Meta-regressions were used to explore effects of age, sex, and sample size on gyrification differences. There were no significant differences in gyrification across groups. Qualitative synthesis of remaining ASD studies highlighted heterogeneity in findings. Large-scale ADHD studies reported no differences in gyrification between cases and controls suggesting that, similar to ASD, there is currently no evidence of differences in gyrification morphology compared with controls. Larger, longitudinal studies are needed to further clarify the effects of age, sex, and IQ on cortical gyrification in these NDDs.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGharehgazlou, A., Freitas, C., Ameis, S. H., Taylor, M. J., Lerch, J. P., Radua, J., & Anagnostou, E. (2021). Cortical gyrification morphology in individuals with ASD and ADHD across the lifespan: a systematic review and meta-analysis. Cerebral Cortex, 31(5), 2653-2669. doi: 10.1093/cercor/bhaa381pt_PT
dc.identifier.doi10.1093/cercor/bhaa381pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/4322
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Presspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAttention-deficit hyperactivity disorderpt_PT
dc.subjectAutism spectrum disorderpt_PT
dc.subjectCortical gyrificationpt_PT
dc.subjectlGIpt_PT
dc.subjectStructural MRIpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências da Vidapt_PT
dc.titleCortical gyrification morphology in individuals with ASD and ADHD across the lifespan: a systematic review and meta-analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2669pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage2653pt_PT
oaire.citation.titleCerebral Cortexpt_PT
oaire.citation.volume31pt_PT
person.familyNameDe Barros Freitas
person.givenNameCarina Patrícia
person.identifier.ciencia-id1616-9C71-0359
person.identifier.orcid0000-0002-3713-9386
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2caaa44a-cb70-4016-ade0-2426574e24df
relation.isAuthorOfPublication.latestForDiscovery2caaa44a-cb70-4016-ade0-2426574e24df

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