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Injectable hybrid laponite/alginate hydrogels for sustained release of methylene blue
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Orientador(es)
Resumo(s)
The incorporation of biocompatible Laponite (LP) into alginate hydrogels greatly increases the drug encapsulation efficiency of methylene blue (MB). By raising the LP content from 0 to 0.5 wt.%, the half-release time (t1/2) of MB in oven-dried gels increases from ~2 h to ~10 h, while t1/2 in vacuum-dried gels slightly changes from ~1 h to ~2 h. Increasing LP content together with drying modes can induce the MB release mechanism froma diffusion-controlled release into a swelling-controlled one.
Descrição
Palavras-chave
Laponite Alginate Injectable hybrid hydrogels Drug delivery Release mechanism . Faculdade de Ciências Exatas e da Engenharia
Contexto Educativo
Citação
Li, Y., Santos, J. L., Maciel, D., Tomás, H., & Rodrigues, J. (2011). Injectable hybrid laponite/alginate hydrogels for sustained release of methylene blue. Journal of Controlled Release, 152, e55-e57.
Editora
Elsevier