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Publication
Urinary volatomic profile of traditional tobacco smokers and electronic cigarettes users as a strategy to unveil potential health issues
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Advisor(s)
Abstract(s)
Many harmful and potentially harmful constituents are present in tobacco prod ucts. Cigarette smoke is known to cause different forms of cancer and trigger the
development of chronic diseases. In the last decade, electronic cigarettes have
emerged as a healthier alternative associated to less harmful effects in compar ison to traditional tobacco. However, the lack of standardization of electronic
cigarettes products makes it difficult to establish and compare the real effects
on health of products from different manufacturers. To better understand the
impact of smoking and vaping, the volatomic composition of urine samples
from traditional tobacco smokers and electronic cigarette users was established
and compared with nonsmokers (control group), using headspace solid-phase
microextraction combined with gas chromatography–mass spectrometry. A total
of 45 urinary volatile organic metabolites belonging to different chemical fami lies were identified in the urine of the studied groups. Benzene derivatives, ter penes, and aromatics were the chemical families that contributed the most to the
urinary profile of smokers. The vapers urinary volatomic pattern was also domi nated by terpenes and aromatics, in addition to alcohols. The orthogonal partial
least squares-discriminant analysis of the data obtained indicated that the uri nary profile of vapers is more closely related to the control group, reinforcing
the hypothesis of the lowest harmfulness of electronic cigarettes. Further studies
recruiting a higher number of subjects are therefore necessary to consolidate the
data obtained.
Description
Keywords
Electronic cigarettes Gas chromatography-mass spectrometry Headspace solid-phase microextraction Tobacco Urinary volatile organic metabolites . Faculdade de Ciências Exatas e da Engenharia Centro de Química da Madeira
Citation
Berenguer C, Pereira JAM, Câmara JS. Urinary volatomic profile of traditional tobacco smokers and electronic cigarettes users as a strategy to unveil potential healthy issues. J Sep Sci. 2022;45:582–593. https://doi.org/10.1002/jssc.202100671
Publisher
Wiley-VCH Verlag