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Urinary volatomic profile of traditional tobacco smokers and electronic cigarettes users as a strategy to unveil potential health issues

2021Journal article Open access
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dc.contributor.authorBerenguer, Cristina
dc.contributor.authorPereira, Jorge A. M.
dc.contributor.authorCâmara, José S.
dc.date.accessioned2022-10-14T10:53:00Z
dc.date.available2022-10-14T10:53:00Z
dc.date.issued2021
dc.description.abstractMany harmful and potentially harmful constituents are present in tobacco prod ucts. Cigarette smoke is known to cause different forms of cancer and trigger the development of chronic diseases. In the last decade, electronic cigarettes have emerged as a healthier alternative associated to less harmful effects in compar ison to traditional tobacco. However, the lack of standardization of electronic cigarettes products makes it difficult to establish and compare the real effects on health of products from different manufacturers. To better understand the impact of smoking and vaping, the volatomic composition of urine samples from traditional tobacco smokers and electronic cigarette users was established and compared with nonsmokers (control group), using headspace solid-phase microextraction combined with gas chromatography–mass spectrometry. A total of 45 urinary volatile organic metabolites belonging to different chemical fami lies were identified in the urine of the studied groups. Benzene derivatives, ter penes, and aromatics were the chemical families that contributed the most to the urinary profile of smokers. The vapers urinary volatomic pattern was also domi nated by terpenes and aromatics, in addition to alcohols. The orthogonal partial least squares-discriminant analysis of the data obtained indicated that the uri nary profile of vapers is more closely related to the control group, reinforcing the hypothesis of the lowest harmfulness of electronic cigarettes. Further studies recruiting a higher number of subjects are therefore necessary to consolidate the data obtained.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBerenguer C, Pereira JAM, Câmara JS. Urinary volatomic profile of traditional tobacco smokers and electronic cigarettes users as a strategy to unveil potential healthy issues. J Sep Sci. 2022;45:582–593. https://doi.org/10.1002/jssc.202100671pt_PT
dc.identifier.doi10.1002/jssc.202100671pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/4706
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWiley-VCH Verlagpt_PT
dc.relationMadeira Chemistry Research Centre
dc.relationMadeira Chemistry Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectElectronic cigarettespt_PT
dc.subjectGas chromatography-mass spectrometrypt_PT
dc.subjectHeadspace solid-phase microextractionpt_PT
dc.subjectTobaccopt_PT
dc.subjectUrinary volatile organic metabolitespt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleUrinary volatomic profile of traditional tobacco smokers and electronic cigarettes users as a strategy to unveil potential health issuespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00674%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00674%2F2020/PT
oaire.citation.endPage593pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage582pt_PT
oaire.citation.titleJournal of Separation Sciencept_PT
oaire.citation.volume45pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameBerenguer
person.familyNameAugusto Machado Pereira
person.familyNameCâmara
person.givenNameCristina
person.givenNameJorge
person.givenNameJosé
person.identifierG-3003-2013
person.identifier.ciencia-idA813-68FE-C3C3
person.identifier.ciencia-idEC12-EE8F-50E8
person.identifier.ciencia-id481C-08CE-90E5
person.identifier.orcid0000-0002-1762-1175
person.identifier.orcid0000-0003-0316-5348
person.identifier.orcid0000-0003-1965-3151
person.identifier.scopus-author-id10140393000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicatione10d78be-e547-4d25-92b5-06a997ed78da
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