HLA‐A polymorphisms in four ethnic groups from Guinea‐Bissau (West Africa) inferred from sequence‐based typing

Spínola, C.; Bruges-Armas, J.; Brehm, A.; Spínola, H.

http://hdl.handle.net/10400.13/2152

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Abstract(s)

Human leukocyte antigen (HLA)-A locus polymorphisms were examined at highresolution level, using sequence-based typing, in the four most representative Guinea-Bissau(NorthwestAfrica)ethnicgroups:Balanta,Bijago´ s,FulaandPapel. DespitetheFulagrouphavingsignificantdifferenceswhencomparedwiththeother three ethnic groups, all four groups most likely received a genetic input from non sub-Saharans. The Bijago´ s and Papel groups showed similarities to neighboring populations from Mali and Senegal. The Balanta, despite their oral tradition of an East Africa origin, show affinities to Cameroon populations, highly influenced by Bantu migrations. These results are congruent with historical sources and other genetic studies that support the finding that the Guinea-Bissau genetic pool was influenced by several migrations from North Africa, Sahara and East Africa.

Keywords

HLA-A Sequence-based typing Sub-Saharan populations Guinea-Bissau . Faculdade de Ciências da Vida

URI

http://hdl.handle.net/10400.13/2152

Citation

Spínola, C., Bruges‐Armas, J., Brehm, A., & Spinola, H. (2008). HLA‐A polymorphisms in four ethnic groups from Guinea‐Bissau (West Africa) inferred from sequence‐based typing. Tissue Antigens, 72(6), 593-598.