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Publicação
Structural/Functional Matches and Divergences of Phytoprostanes and Phytofurans with Bioactive Human Oxylipins
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Orientador(es)
Resumo(s)
Structure-activity relationship (SAR) constitutes a crucial topic to discover new bioactive
molecules. This approach initiates with the comparison of a target candidate with a molecule or a
collection of molecules and their attributed biological functions to shed some light in the details of one
or more SARs and subsequently using that information to outline valuable application of the newly
identified compounds. Thus, while the empiric knowledge of medicinal chemistry is critical to these
tasks, the results retrieved upon dedicated experimental demonstration retrieved resorting to modern
high throughput analytical approaches and techniques allow to overwhelm the constraints adduced
so far to the successful accomplishment of such tasks. Therefore, the present work reviews critically
the evidences reported to date on the occurrence of phytoprostanes and phytofurans in plant foods,
and the information available on their bioavailability and biological activity, shedding some light on
the expectation waken up due to their structural similarities with prostanoids and isoprostanes.
Descrição
Palavras-chave
Plant oxylipins Mammals oxylipins Structural analogy Biological activity SAR . Faculdade de Ciências Exatas e da Engenharia
Contexto Educativo
Citação
Medina, S., Gil-Izquierdo, Á., Durand, T., Ferreres, F., & Domínguez-Perles, R. (2018). Structural/functional matches and divergences of phytoprostanes and phytofurans with bioactive human oxylipins. Antioxidants, 7(11), 165.
Editora
MDPI