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Structural/Functional Matches and Divergences of Phytoprostanes and Phytofurans with Bioactive Human Oxylipins

2018Journal article Open access
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dc.contributor.authorMedina, Sonia
dc.contributor.authorGil-Izquierdo, Angel
dc.contributor.authorDurand, Thierry
dc.contributor.authorFerreres, Federico
dc.contributor.authorDomínguez-Perles, Raúl
dc.date.accessioned2024-02-07T15:50:35Z
dc.date.available2024-02-07T15:50:35Z
dc.date.issued2018
dc.description.abstractStructure-activity relationship (SAR) constitutes a crucial topic to discover new bioactive molecules. This approach initiates with the comparison of a target candidate with a molecule or a collection of molecules and their attributed biological functions to shed some light in the details of one or more SARs and subsequently using that information to outline valuable application of the newly identified compounds. Thus, while the empiric knowledge of medicinal chemistry is critical to these tasks, the results retrieved upon dedicated experimental demonstration retrieved resorting to modern high throughput analytical approaches and techniques allow to overwhelm the constraints adduced so far to the successful accomplishment of such tasks. Therefore, the present work reviews critically the evidences reported to date on the occurrence of phytoprostanes and phytofurans in plant foods, and the information available on their bioavailability and biological activity, shedding some light on the expectation waken up due to their structural similarities with prostanoids and isoprostanes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMedina, S., Gil-Izquierdo, Á., Durand, T., Ferreres, F., & Domínguez-Perles, R. (2018). Structural/functional matches and divergences of phytoprostanes and phytofurans with bioactive human oxylipins. Antioxidants, 7(11), 165.pt_PT
dc.identifier.doi10.3390/antiox7110165pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/5542
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPlant oxylipinspt_PT
dc.subjectMammals oxylipinspt_PT
dc.subjectStructural analogypt_PT
dc.subjectBiological activitypt_PT
dc.subjectSARpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.titleStructural/Functional Matches and Divergences of Phytoprostanes and Phytofurans with Bioactive Human Oxylipinspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue11pt_PT
oaire.citation.startPage165pt_PT
oaire.citation.titleAntioxidantspt_PT
oaire.citation.volume7pt_PT
person.familyNameMedina
person.familyNameGil-Izquierdo
person.familyNameDomínguez-Perles
person.givenNameSonia
person.givenNameAngel
person.givenNameRaúl
person.identifier109905
person.identifierj-7456-2013
person.identifier.ciencia-id581A-863C-1DA6
person.identifier.orcid0000-0002-7231-6480
person.identifier.orcid0000-0001-7646-0386
person.identifier.orcid0000-0001-6232-712X
person.identifier.ridM-2479-2014
person.identifier.ridB-5563-2008
person.identifier.scopus-author-id57203612189
person.identifier.scopus-author-id15834014400
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0b7ef59e-0920-4650-b2af-b6faf7ec5478
relation.isAuthorOfPublication58139577-a7b5-4a19-83fa-efe440cc946e
relation.isAuthorOfPublication5a24e768-0e8a-4c33-bd6b-0743c15b7215
relation.isAuthorOfPublication.latestForDiscovery5a24e768-0e8a-4c33-bd6b-0743c15b7215

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