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Multifunctional dendrimer-entrapped gold nanoparticles conjugated with Doxorubicin for pH-responsive drug delivery and targeted computed tomography imaging

2018Journal article Restricted access
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dc.contributor.authorZhu, Jingyi
dc.contributor.authorWang, Guoying
dc.contributor.authorAlves, Carla S.
dc.contributor.authorTomás, Helena
dc.contributor.authorXiong, Zhijuan
dc.contributor.authorShen, Mingwu
dc.contributor.authorRodrigues, João
dc.contributor.authorShi, Xiangyang
dc.date.accessioned2019-06-27T14:33:32Z
dc.date.available2019-06-27T14:33:32Z
dc.date.issued2018
dc.description.abstractNovel theranostic nanocarriers exhibit a desirable potential to treat diseases based on their ability to achieve targeted therapy while allowing for real-time imaging of the disease site. Development of such theranostic platforms is still quite challenging. Herein, we present the construction of multifunctional dendrimer-based theranostic nanosystem to achieve cancer cell chemotherapy and computed tomography (CT) imaging with targeting specificity. Doxorubicin (DOX), a model anticancer drug, was first covalently linked onto the partially acetylated poly(amidoamine) dendrimers of generation 5 (G5) prefunctionalized with folic acid (FA) through acid-sensitive cis-aconityl linkage to form G5·NHAc-FA-DOX conjugates, which were then entrapped with gold (Au) nanoparticles (NPs) to create dendrimer-entrapped Au NPs (Au DENPs). We demonstrate that the prepared DOX-Au DENPs possess an Au core size of 2.8 nm, have 9.0 DOX moieties conjugated onto each dendrimer, and are colloid stable under different conditions. The formed DOX-Au DENPs exhibit a pH-responsive release profile of DOX because of the cis-aconityl linkage, having a faster DOX release rate under a slightly acidic pH condition than under a physiological pH. Importantly, because of the coexistence of targeting ligand FA and Au core NPs as a CT imaging agent, the multifunctional DOX-loaded Au DENPs afford specific chemotherapy and CT imaging of FA receptor-overexpressing cancer cells. The constructed DOX-conjugated Au DENPs hold a promising potential to be utilized for simultaneous chemotherapy and CT imaging of various types of cancer cells.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationZhu, J.; Wang, G.; Alves, C. S.; Tomás, H.; Xiong, Z.; Shen, M.; Rodrigues, J. M. C.; Shi, X.; Multifunctional Dendrimer-Entrapped Gold Nanoparticles Conjugated with Doxorubicin for pH-Responsive Drug Delivery and Targeted Computed Tomography Imaging. Langmuir 2018, 34, 12428-12435.pt_PT
dc.identifier.doi10.1021/acs.langmuir.8b02901pt_PT
dc.identifier.issn0743-7463
dc.identifier.urihttp://hdl.handle.net/10400.13/2438
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Chemical Societypt_PT
dc.relationStrategic Project - UI 674 - 2014
dc.subjectMultifunctional dendrimerpt_PT
dc.subjectGold nanoparticlespt_PT
dc.subjectDoxorubicinpt_PT
dc.subjectpH-responsive drug deliverypt_PT
dc.subjectDrug deliverypt_PT
dc.subjectHydrogen-ion concentrationpt_PT
dc.subjectMetal nanoparticlespt_PT
dc.subjectTheranostic nanomedicinept_PT
dc.subjectComputed tomography imagingpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleMultifunctional dendrimer-entrapped gold nanoparticles conjugated with Doxorubicin for pH-responsive drug delivery and targeted computed tomography imagingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 674 - 2014
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0674%2F2014/PT
oaire.citation.endPage12435pt_PT
oaire.citation.startPage12428pt_PT
oaire.citation.titleLangmuirpt_PT
oaire.citation.volume34pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameAlves
person.familyNameTomás
person.familyNameRodrigues
person.familyNameShi
person.givenNameCarla Sophia
person.givenNameHelena
person.givenNameJoão
person.givenNameXiangyang
person.identifier556975
person.identifier.ciencia-id4D14-D31E-A8BE
person.identifier.ciencia-idA81C-620E-DD6A
person.identifier.ciencia-idBA11-1437-B948
person.identifier.orcid0000-0002-8891-5234
person.identifier.orcid0000-0002-7856-2041
person.identifier.orcid0000-0003-4552-1953
person.identifier.orcid0000-0001-6785-6645
person.identifier.ridE-5991-2010
person.identifier.ridB-6816-2008
person.identifier.ridA-1289-2007
person.identifier.scopus-author-id11438813200
person.identifier.scopus-author-id6508104177
person.identifier.scopus-author-id9233278800
person.identifier.scopus-author-id7402953116
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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