Poly(alkylidenamines) dendrimers as scaffolds for the preparation of low-generation ruthenium based metallodendrimers

Rodrigues, João; Jardim, Manuel G.; Figueira, João; Gouveia, Marisol; Tomás, Helena; Rissanen, Kari

http://hdl.handle.net/10400.13/2403

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Abstract(s)

The aim of this article is to highlight the use of nitrile-functionalized poly(alkylidenamines) dendrimers as building blocks for the preparation of low-generation ruthenium based cationic metallodendrimers having in view potential biomedical applications. Air-stable poly(alkylidenamines) nitrile dendrimers, peripherally functionalized with the ruthenium moieties [Ru(Z5-C5H5)(PPh3)2]+ or [RuCl(dppe)2]+, have been prepared, characterized and are being studied for their anticancer activity. The followed strategy is based on the biological advantages associated with low-generation dendrimers, the known activity of ruthenium compounds as anticancer drugs and the stability of these dendrimers at the physiological temperature.

Keywords

Poly(alkylidenamines) dendrimers Preparation of low-generation ruthenium Low-generation ruthenium Ruthenium Metallodendrimers . Faculdade de Ciências Exatas e da Engenharia Centro de Química da Madeira

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http://hdl.handle.net/10400.13/2403

Citation

Rodrigues, J., Jardim, M. G., Figueira, J., Gouveia, M., Tomas, H., & Rissanen, K. (2011). Poly (alkylidenamines) dendrimers as scaffolds for the preparation of low-generation ruthenium based metallodendrimers. New Journal of Chemistry, 35(10), 1938-1943.