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Investigation of urinary volatomic alterations in head and neck cancer: a non-invasive approach towards diagnosis and prognosis

2017Journal article Open access
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dc.contributor.authorTaware, Ravindra
dc.contributor.authorTaunk, Khushman
dc.contributor.authorPereira, Jorge A. M.
dc.contributor.authorDhakne, Rahul
dc.contributor.authorKannan, Narayanan
dc.contributor.authorSoneji, Dharmesh
dc.contributor.authorCâmara, José S.
dc.contributor.authorNagarajaram, H. A.
dc.contributor.authorRapole, Srikanth
dc.date.accessioned2021-12-02T12:05:21Z
dc.date.available2021-12-02T12:05:21Z
dc.date.issued2017
dc.description.abstractIntroduction Head and neck cancer (HNC), like many other forms of cancer, is usually detected in advanced stages, causing poor survival outcomes. Lack of specific and sensi tive screening markers for early detection of HNC has wors ened the scenario for the patients as well as the clinicians. Therefore, identification of efficient, noninvasive and afford able screening marker/methodology with high specificity and sensitivity is imminent need of situation. Objectives This study aims to identify and characterize urinary volatomic alterations specific to HNC. Methods Volatomic analysis of urine samples collected from HNC patients (n=29) and healthy controls (n=31) was performed using headspace solid phase microextraction coupled to gas chromatography mass spectrometry (GC– MS). Both univariate and multivariate statistical approaches were used to investigate HNC specific volatomic alterations. Results Statistical analysis revealed a total of 28 metabo lites with highest contribution towards discrimination of HNC patients from healthy controls (VIP >1, p < 0.05, Log2 FC ≥0.58/≤−0.57). The discrimination efficiency and accuracy of urinary VOCs was ascertained by ROC curve analysis that allowed the identification of four metabolites viz. 2,6-dimethyl-7-octen-2-ol, 1-butanol, p-xylene and 4-methyl-2-heptanone with highest sensitivity and speci ficity to discriminate HNC patients from healthy controls. Further, the metabolic pathway analysis identified several dysregulated pathways in HNC patients and their detailed investigations could unravel novel mechanistic insights into the disease pathophysiology. Conclusion Overall, this study provides valuable finger print of the volatile profile of HNC patients, which in turn, might help in improving the current understanding of this form of cancer and lead to the development of non-invasive approaches for HNC diagnosis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTaware, R., Taunk, K., Pereira, J. A., Dhakne, R., Kannan, N., Soneji, D., ... & Rapole, S. (2017). Investigation of urinary volatomic alterations in head and neck cancer: a non-invasive approach towards diagnosis and prognosis. Metabolomics, 13(10), 1-11. DOI 10.1007/s11306-017-1251-6pt_PT
dc.identifier.doi10.1007/s11306-017-1251-6pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/3878
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationStrategic Project - UI 674 - 2014
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectHead and neck cancerpt_PT
dc.subjectVolatomicspt_PT
dc.subjectVOMspt_PT
dc.subjectGC–MSpt_PT
dc.subjectUrinary markerspt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleInvestigation of urinary volatomic alterations in head and neck cancer: a non-invasive approach towards diagnosis and prognosispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 674 - 2014
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0674%2F2014/PT
oaire.citation.issue10pt_PT
oaire.citation.titleMetabolomicspt_PT
oaire.citation.volume13pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameTaware
person.familyNameTAUNK
person.familyNameAugusto Machado Pereira
person.familyNameCâmara
person.givenNameRavindra
person.givenNameKHUSHMAN
person.givenNameJorge
person.givenNameJosé
person.identifierG-3003-2013
person.identifier.ciencia-idEC12-EE8F-50E8
person.identifier.ciencia-id481C-08CE-90E5
person.identifier.orcid0000-0001-7893-2850
person.identifier.orcid0000-0003-2293-2936
person.identifier.orcid0000-0003-0316-5348
person.identifier.orcid0000-0003-1965-3151
person.identifier.scopus-author-id57195429801
person.identifier.scopus-author-id10140393000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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