Prodrug Systems (II): a perspective of Polymer-based Doxorubicin Prodrug systems towards chemotherapy

Wang, Zhao; Olim, Filipe; Sun, Jingjing; Neves, Ana Rute; Mendes, Fátima; Tomás, Helena; Sheng, Ruilong

http://hdl.handle.net/10400.13/3821

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Abstract(s)

Utilizing biocompatible polymers as platforms to covalently conjugate with chemotherapeutics to construct polymer-based prodrugs and their nano drug delivery systems has attracted great attention in recent years. This perspective reviewed state-of-the-arts for polymer-based doxorubicin prodrugs and the related nanodelivery systems, including: (1) pH-responsive polymer-doxorubicin prodrugs/conjugates; (2) pH/redox dual responsive prodrugs/conjugates; (3) reactive oxygen species/hypoxia-responsive polymer-doxorubicin prodrugs; (4) tumor receptor targeting polymer prodrugs; (5) enzyme-responsive polymer-doxorubicin prodrugs. Finally, possible future perspectives were also stated and discussed.

Keywords

Polymers Doxorubicin Prodrug Stimuli-responsive Drug delivery Nanosystem . Faculdade de Ciências Exatas e da Engenharia Centro de Química da Madeira

URI

http://hdl.handle.net/10400.13/3821

Citation

Wang, Z., Olim, F., Sun, J., Neves, A. R., Mendes, F., Tomás, H., & Sheng, R. Prodrug Systems (II): a perspective of Polymer-based Doxorubicin Prodrug systems towards chemotherapy. Medicine Research. DOI: 10.21127/yaoyimr20200023