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Publicação
Prodrug Systems (II): a perspective of Polymer-based Doxorubicin Prodrug systems towards chemotherapy
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Orientador(es)
Resumo(s)
Utilizing biocompatible polymers as platforms to covalently conjugate with chemotherapeutics to
construct polymer-based prodrugs and their nano drug delivery systems has attracted great attention in recent
years. This perspective reviewed state-of-the-arts for polymer-based doxorubicin prodrugs and the related
nanodelivery systems, including: (1) pH-responsive polymer-doxorubicin prodrugs/conjugates; (2) pH/redox dual responsive prodrugs/conjugates; (3) reactive oxygen species/hypoxia-responsive polymer-doxorubicin
prodrugs; (4) tumor receptor targeting polymer prodrugs; (5) enzyme-responsive polymer-doxorubicin prodrugs.
Finally, possible future perspectives were also stated and discussed.
Descrição
Palavras-chave
Polymers Doxorubicin Prodrug Stimuli-responsive Drug delivery Nanosystem . Faculdade de Ciências Exatas e da Engenharia Centro de Química da Madeira
Contexto Educativo
Citação
Wang, Z., Olim, F., Sun, J., Neves, A. R., Mendes, F., Tomás, H., & Sheng, R. Prodrug Systems (II): a perspective of Polymer-based Doxorubicin Prodrug systems towards chemotherapy. Medicine Research. DOI: 10.21127/yaoyimr20200023
Editora
Medicine Research