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Prodrug Systems (II): a perspective of Polymer-based Doxorubicin Prodrug systems towards chemotherapy

2021Journal article Open access
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dc.contributor.authorWang, Zhao
dc.contributor.authorOlim, Filipe
dc.contributor.authorSun, Jingjing
dc.contributor.authorNeves, Ana Rute
dc.contributor.authorMendes, Fátima
dc.contributor.authorTomás, Helena
dc.contributor.authorSheng, Ruilong
dc.date.accessioned2021-11-16T14:44:17Z
dc.date.available2021-11-16T14:44:17Z
dc.date.issued2021
dc.description.abstractUtilizing biocompatible polymers as platforms to covalently conjugate with chemotherapeutics to construct polymer-based prodrugs and their nano drug delivery systems has attracted great attention in recent years. This perspective reviewed state-of-the-arts for polymer-based doxorubicin prodrugs and the related nanodelivery systems, including: (1) pH-responsive polymer-doxorubicin prodrugs/conjugates; (2) pH/redox dual responsive prodrugs/conjugates; (3) reactive oxygen species/hypoxia-responsive polymer-doxorubicin prodrugs; (4) tumor receptor targeting polymer prodrugs; (5) enzyme-responsive polymer-doxorubicin prodrugs. Finally, possible future perspectives were also stated and discussed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationWang, Z., Olim, F., Sun, J., Neves, A. R., Mendes, F., Tomás, H., & Sheng, R. Prodrug Systems (II): a perspective of Polymer-based Doxorubicin Prodrug systems towards chemotherapy. Medicine Research. DOI: 10.21127/yaoyimr20200023pt_PT
dc.identifier.doi10.21127/yaoyimr20200023pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/3821
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMedicine Researchpt_PT
dc.relationMadeira Chemistry Research Centre
dc.relationMadeira Chemistry Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPolymerspt_PT
dc.subjectDoxorubicinpt_PT
dc.subjectProdrugpt_PT
dc.subjectStimuli-responsivept_PT
dc.subjectDrug deliverypt_PT
dc.subjectNanosystempt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleProdrug Systems (II): a perspective of Polymer-based Doxorubicin Prodrug systems towards chemotherapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00674%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00674%2F2020/PT
oaire.citation.issue5pt_PT
oaire.citation.startPage200023pt_PT
oaire.citation.titleMedicine Researchpt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameOlim
person.familyNameNeves
person.familyNameMendes Ferreira
person.familyNameTomás
person.familyNameSheng
person.givenNameFilipe
person.givenNameAna Rute
person.givenNameFátima José
person.givenNameHelena
person.givenNameRuilong
person.identifierAAV-3293-2020
person.identifier556975
person.identifierhttps://scholar.google.ca/citations?user=YCheaFsAAAAJ&hl=en
person.identifier.ciencia-id911A-2894-E357
person.identifier.ciencia-idA51A-E760-E8B8
person.identifier.ciencia-id8118-A986-96B2
person.identifier.ciencia-id4D14-D31E-A8BE
person.identifier.ciencia-idC019-C809-403B
person.identifier.orcid0000-0001-8878-2067
person.identifier.orcid0000-0003-4262-5837
person.identifier.orcid0000-0003-0714-929X
person.identifier.orcid0000-0002-7856-2041
person.identifier.orcid0000-0002-3303-3832
person.identifier.ridO-6395-2018
person.identifier.ridH-3743-2013
person.identifier.ridE-5991-2010
person.identifier.scopus-author-id56731303900
person.identifier.scopus-author-id6508104177
person.identifier.scopus-author-id7005472737
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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