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Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours
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Orientador(es)
Resumo(s)
Cell functions can be mediated through their interactions
with the microenvironments, which highly depend on the
surface state of the substrate. However, how to finely adjust
the surface of biomaterials is still very challenging. In this
study, poly(D,L-lactide) (PDLLA) with high molecular weight
was synthesized via ring opening polymerization, which
was hot-pressed into PDLLA membrane. In order to modify
the hydrophobicity of the membrane (a limiting factor for
its biomedical application), an amphiphilic monomethoxyl
poly(ethylene glycol)-b-poly(D,L-lactide) (PEG-PDLLA) was
selected to improve its surface hydrophilicity through a
simple self-assembly approach. It was found that the
contact angles of the modified membrane can be well
controlled by variation of PEG-PDLLA concentrations. In
vitro cell biological study indicates that optimized cell
adhesion can be achieved on the modified membrane with
a contact angle of around 50° via its self-assembly with
an ethanol/water solution of PEG-PDLA (35 mg ml−1). The
surface modification of the membrane also changed its
biodegradation property in the process of its incubation period
up to 240 days. The surface modification method may afford
an effective way for adjustment of the surface (interface)
of membrane (scaffolds) of different biomaterials, beyond
polylactide.
Descrição
Palavras-chave
Ring opening polymerization Poly(D,L-lactide) membrane Amphiphilic poly(ethylene glycol)-b-poly(D,L-lactide) Surface hydrophilicity Biodegradation Cell behaviours . Faculdade de Ciências Exatas e da Engenharia
Contexto Educativo
Citação
Yang, Y., Qiu, X., Sun, Y., Wang, Y., Wang, J., Li, Y., & Liu, C. (2018). Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours. Royal Society Open Science, 5(1), 170868.
Editora
The Royal Society