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Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours

2018Journal article Open access
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dc.contributor.authorYang, Yang
dc.contributor.authorQiu, Xiaofeng
dc.contributor.authorSun, Yi
dc.contributor.authorWang, Yifeng
dc.contributor.authorWang, Jine
dc.contributor.authorLi, Yulin
dc.contributor.authorLiu, Changsheng
dc.date.accessioned2023-11-03T14:42:41Z
dc.date.available2023-11-03T14:42:41Z
dc.date.issued2018
dc.description.abstractCell functions can be mediated through their interactions with the microenvironments, which highly depend on the surface state of the substrate. However, how to finely adjust the surface of biomaterials is still very challenging. In this study, poly(D,L-lactide) (PDLLA) with high molecular weight was synthesized via ring opening polymerization, which was hot-pressed into PDLLA membrane. In order to modify the hydrophobicity of the membrane (a limiting factor for its biomedical application), an amphiphilic monomethoxyl poly(ethylene glycol)-b-poly(D,L-lactide) (PEG-PDLLA) was selected to improve its surface hydrophilicity through a simple self-assembly approach. It was found that the contact angles of the modified membrane can be well controlled by variation of PEG-PDLLA concentrations. In vitro cell biological study indicates that optimized cell adhesion can be achieved on the modified membrane with a contact angle of around 50° via its self-assembly with an ethanol/water solution of PEG-PDLA (35 mg ml−1). The surface modification of the membrane also changed its biodegradation property in the process of its incubation period up to 240 days. The surface modification method may afford an effective way for adjustment of the surface (interface) of membrane (scaffolds) of different biomaterials, beyond polylactide.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationYang, Y., Qiu, X., Sun, Y., Wang, Y., Wang, J., Li, Y., & Liu, C. (2018). Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours. Royal Society Open Science, 5(1), 170868.pt_PT
dc.identifier.doi10.1098/rsos.170868pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/5345
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherThe Royal Societypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectRing opening polymerizationpt_PT
dc.subjectPoly(D,L-lactide) membranept_PT
dc.subjectAmphiphilic poly(ethylene glycol)-b-poly(D,L-lactide)pt_PT
dc.subjectSurface hydrophilicitypt_PT
dc.subjectBiodegradationpt_PT
dc.subjectCell behaviourspt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.titleDevelopment of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviourspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPage170868pt_PT
oaire.citation.titleRoyal Society Open Sciencept_PT
oaire.citation.volume5pt_PT
person.familyNameLi
person.givenNameYulin
person.identifier.orcid0000-0001-5569-1038
person.identifier.ridA-4082-2013
person.identifier.scopus-author-id55718977200
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationde21a0a9-a5a2-4521-b0e4-5902704f9bb0
relation.isAuthorOfPublication.latestForDiscoveryde21a0a9-a5a2-4521-b0e4-5902704f9bb0

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