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Publication
Hypoglycemic, anti-glycation and antioxidant in vitro properties of two Vaccinium species from Macaronesia: A relation to their phenolic composition
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Advisor(s)
Abstract(s)
Vaccinium cylindraceaeum (Azores blueberry) and V. padifolium (Madeira blueberry) are two Portuguese endemic
species, which phytochemical composition and beneficial properties lack scientific validation. In this work, their
potential in vitro inhibitory effects against key enzymes linked to type 2 diabetes and obesity and glycation of
proteins were evaluated. Anthocyanins were predominant in fruits, while hydroxycinnamic acids (in particular
5-O-caffeoylquinic acid) and flavonoids were the main compounds in leaves. Vaccinium extracts showed effective
inhibitions of glucosidases and glycation of proteins and mild activity towards α-amylase and pancreatic
lipase (by comparison with reference compounds). Phenolic composition was strongly correlated with reported
bioactivities. In fact, 5-O-caffeoylquinic can be considered one of the main hypoglycemic and anti-glycation
agents of analysed extracts. Consumption of both Vaccinium species should be encouraged since berries could
offer a dietary option in the prevention and control of diabetes and obesity, while leaves are good candidates for
development of nutraceuticals.
Description
Keywords
Vaccinium cylindraceum Vaccinium padifolium Polyphenols Digestive enzymes inhibition Anti-glycation Antioxidant activity . Faculdade de Ciências Exatas e da Engenharia Centro de Química da Madeira
Citation
Spínola, V., Pinto, J., & Castilho, P. C. (2018). Hypoglycemic, anti-glycation and antioxidant in vitro properties of two Vaccinium species from Macaronesia: A relation to their phenolic composition. Journal of Functional Foods, 40, 595-605. 10.1016/j.jff.2017.12.002
Publisher
International Society for Nutraceuticals and Functional Foods (ISNFF)