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Hypoglycemic, anti-glycation and antioxidant in vitro properties of two Vaccinium species from Macaronesia: A relation to their phenolic composition

2018Journal article Open access
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dc.contributor.authorSpínola, Vítor
dc.contributor.authorPinto, Joana
dc.contributor.authorCastilho, Paula C.
dc.date.accessioned2021-03-26T09:56:40Z
dc.date.available2021-03-26T09:56:40Z
dc.date.issued2018
dc.description.abstractVaccinium cylindraceaeum (Azores blueberry) and V. padifolium (Madeira blueberry) are two Portuguese endemic species, which phytochemical composition and beneficial properties lack scientific validation. In this work, their potential in vitro inhibitory effects against key enzymes linked to type 2 diabetes and obesity and glycation of proteins were evaluated. Anthocyanins were predominant in fruits, while hydroxycinnamic acids (in particular 5-O-caffeoylquinic acid) and flavonoids were the main compounds in leaves. Vaccinium extracts showed effective inhibitions of glucosidases and glycation of proteins and mild activity towards α-amylase and pancreatic lipase (by comparison with reference compounds). Phenolic composition was strongly correlated with reported bioactivities. In fact, 5-O-caffeoylquinic can be considered one of the main hypoglycemic and anti-glycation agents of analysed extracts. Consumption of both Vaccinium species should be encouraged since berries could offer a dietary option in the prevention and control of diabetes and obesity, while leaves are good candidates for development of nutraceuticals.pt_PT
dc.description.sponsorshipThe authors are grateful to Cândida Dias from Flores Island (Azores archipelago), to Francisco Fernandes and José Carvalho from Madeira Botanical Garden and to Funchal Ecological Park for the supply and identification of plant material.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSpínola, V., Pinto, J., & Castilho, P. C. (2018). Hypoglycemic, anti-glycation and antioxidant in vitro properties of two Vaccinium species from Macaronesia: A relation to their phenolic composition. Journal of Functional Foods, 40, 595-605. 10.1016/j.jff.2017.12.002pt_PT
dc.identifier.doi10.1016/j.jff.2017.12.002pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/3206
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherInternational Society for Nutraceuticals and Functional Foods (ISNFF)pt_PT
dc.relationNUTRACEUTICALS AND FUNCTIONAL FOODS FOR DIABETES AND OBESITY CONTROL
dc.relationStrategic Project - UI 674 - 2014
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectVaccinium cylindraceumpt_PT
dc.subjectVaccinium padifoliumpt_PT
dc.subjectPolyphenolspt_PT
dc.subjectDigestive enzymes inhibitionpt_PT
dc.subjectAnti-glycationpt_PT
dc.subjectAntioxidant activitypt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleHypoglycemic, anti-glycation and antioxidant in vitro properties of two Vaccinium species from Macaronesia: A relation to their phenolic compositionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNUTRACEUTICALS AND FUNCTIONAL FOODS FOR DIABETES AND OBESITY CONTROL
oaire.awardTitleStrategic Project - UI 674 - 2014
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F84672%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0674%2F2014/PT
oaire.citation.endPage605pt_PT
oaire.citation.startPage595pt_PT
oaire.citation.titleJournal of Functional Foodspt_PT
oaire.citation.volume40pt_PT
oaire.fundingStreamOE
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSpínola
person.familyNameNunes Pinto
person.familyNameCastilho
person.givenNameVítor
person.givenNameJoana Carolina
person.givenNamePaula C
person.identifierA-4412-2013
person.identifier.ciencia-id0412-6D53-3A09
person.identifier.ciencia-id6D15-8C69-A2E0
person.identifier.orcid0000-0003-2456-8613
person.identifier.orcid0000-0002-8303-4286
person.identifier.scopus-author-id54881258000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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