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Chemically heterogeneous carbon dots enhanced cholesterol detection by MALDI TOF mass spectrometry

2021Journal article Open access
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dc.contributor.authorHoudová, Dominika
dc.contributor.authorSoto, Juan
dc.contributor.authorCastro, Rita
dc.contributor.authorRodrigues, João
dc.contributor.authorSoledad Pino-González, Mª
dc.contributor.authorPetković, Marijana
dc.contributor.authorBandosz, Teresa J
dc.contributor.authorAlgarra, Manuel
dc.date.accessioned2022-02-16T15:40:53Z
dc.date.available2022-02-16T15:40:53Z
dc.date.issued2021
dc.description.abstractA binary system composed of carbon dots (CDs) and N-doped CDs (N-CDs) embedded in an organic matrix was used for the analysis of cholesterol by MALDI (matrix-assisted laser desorption and ionization time of-flight) mass spectrometry, as a model for detection of small, biologically relevant molecules. The results showed that both CDs are sensitive to the cholesterol and can be used either alone or in a binary system with 2,5-dihydroxybenzoic acid (DHB) to enhance the detection process. It was found that both COOH and NH2 groups on CDs surface contributed to the enhancement in the cholesterol detection by MALDI mass spectrometry in the presence of inorganic cations. Nevertheless, in the presence of NaCl, N-CDs led to a better reproducibility of results. It was due to the coexistence of positive and negative charge on N-CDs surface that led to a homogeneous analyte/substrate distribution, which is an important detection parameter. The enhancing effect of carbon dots was linked to a negative Gibbs energy of the complex formation between CDs, Na+ , cholesterol and DHB, and it was supported by theoretical calcula tions. Moreover, upon the addition of CDs/N-CDs, such features as a low ionization potential, vertical excitation, dipole moment and oscillator strength positively affected the cholesterol detection by MALDI in the presence of Na+.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationHoudová, D., Soto, J., Castro, R., Rodrigues, J., Pino-González, M. S., Petković, M., ... & Algarra, M. (2021). Chemically heterogeneous carbon dots enhanced cholesterol detection by MALDI TOF mass spectrometry. Journal of Colloid and Interface Science, 591, 373-383. https://doi.org/10.1016/j.jcis.2021.02.004pt_PT
dc.identifier.doi10.1016/j.jcis.2021.02.004pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/4085
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationMadeira Chemistry Research Centre
dc.relationMadeira Chemistry Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCholesterolpt_PT
dc.subjectMALDI TOFpt_PT
dc.subjectCarbon dotspt_PT
dc.subjectN-doped Carbon dotspt_PT
dc.subjectDFT calculationspt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleChemically heterogeneous carbon dots enhanced cholesterol detection by MALDI TOF mass spectrometrypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00674%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00674%2F2020/PT
oaire.citation.endPage383pt_PT
oaire.citation.startPage373pt_PT
oaire.citation.titleJournal of Colloid and Interface Sciencept_PT
oaire.citation.volume591pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCastro
person.familyNameRodrigues
person.givenNameRita
person.givenNameJoão
person.identifier.ciencia-id8314-881E-4986
person.identifier.ciencia-idA81C-620E-DD6A
person.identifier.orcid0000-0002-9337-062X
person.identifier.orcid0000-0003-4552-1953
person.identifier.ridA-2497-2013
person.identifier.ridB-6816-2008
person.identifier.scopus-author-id9233278800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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