Dendrimers in combination with natural products and analogues as anti-cancer agents

Mignani, Serge; Rodrigues, João; Tomás, Helena; Zablocka, Maria; Shi, Xiangyang; Caminade, Anne-marie; Majoral, Jean-Pierre

http://hdl.handle.net/10400.13/2434

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Abstract(s)

For the first time, an overview of dendrimers in combination with natural products and analogues as anti-cancer agents is presented. This reflects the development of drug delivery systems, such as dendrimers, to tackle cancers. The most significant advantages of using dendrimers in nanomedicine are their high biocompatibility, good water solubility, and their entry - with or without encapsulated, complexed or conjugated drugs - through an endocytosis process. This strategy has accelerated over the years in order to develop nanosystems as nanocarriers, to decrease the intrinsic toxicity of anti-cancer agents, to decrease the drug side effects, to increase the efficacy of the treatment, and consequently to improve patient compliance.

Keywords

Dendrimers Drug carriers Drug delivery systems Natural products Nanomedicine Neoplasms . Faculdade de Ciências Exatas e da Engenharia Centro de Química da Madeira

URI

http://hdl.handle.net/10400.13/2434

Citation

Mignani, S., Rodrigues, J., Tomas, H., Zablocka, M., Shi, X., Caminade, A. M., & Majoral, J. P. (2018). Dendrimers in combination with natural products and analogues as anti-cancer agents. Chemical Society Reviews, 47(2), 514-532.