High-density lipoprotein cholesterol level relates to working memory, immediate and delayed cued recall in brazilian older adults: the role of cognitive reserve

Ihle, Andreas; Gouveia, Élvio R.; Gouveia, Bruna R.; Freitas, Duarte L.; Jurema, Jefferson; Tinôco, Maria A.; Kliegel, Matthias

http://hdl.handle.net/10400.13/2178

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Abstract(s)

Aims: The present study set out to investigate the relation of the high-density lipoprotein cholesterol (HDL-C) level to cognitive performance and its interplay with key markers of cognitive reserve in a large sample of older adults. Methods: We assessed tests of working memory, immediate and delayed cued recall in 701 older adults from Amazonas, Brazil. The HDL-C level was derived from fasting blood samples. In addition, we interviewed individuals on their education, past occupation, and cognitive leisure activity. Results: A critically low HDL-C level (<40 mg/dL) was significantly related to lower performance in working memory, immediate and delayed cued recall. Moderation analyses suggested that the relations of the HDL-C level to working memory and delayed cued recall were negligible in individuals with longer education, a higher cognitive level of the job, and greater engagement in cognitive leisure activity. Conclusion: Cognitive reserve accumulated during the life course may reduce the detrimental influences of a critically low HDL-C level on cognitive functioning in old age.

Keywords

High-density lipoprotein cholesterol level Cognitive functioning Cognitive reserve Education Cognitive level of job Cognitive leisure activity Older adults Life course Brasil . Faculdade de Ciências Sociais

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http://hdl.handle.net/10400.13/2178

Citation

Ihle, A., Gouveia, É. R., Gouveia, B. R., Freitas, D. L., Jurema, J., Tinôco, M. A., & Kliegel, M. (2017). High-density lipoprotein cholesterol level relates to working memory, immediate and delayed cued recall in brazilian older adults: the role of cognitive reserve. Dementia and geriatric cognitive disorders, 44(1-2), 84-91.